Residues and Contaminants in Foodstuffs: Extraction, Analytical and Advanced Detection Methods

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Quality and Safety".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 427

Editors


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Guest Editor
Laboratory of Pesticide Residues Analysis (LARP), Department of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil
Interests: food safety; pesticides; veterinary drugs; contaminants; residues; analytical method development; chromatography techniques; mass spectrometry; extraction methods

E-Mail Website
Guest Editor
Laboratory of Pesticide Residues Analysis (LARP), Department of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil
Interests: chromatography; mass spectrometry; high-performance; liquid chromatography; sample preparation; analytical chemistry instrumentation; spectrometry; analytical method development; chemical analysis; extraction

Special Issue Information

Dear Colleagues,

Food safety remains a global priority, as evidenced by the prevalence of residues and contaminants such as pesticides (e.g., glyphosate, neonicotinoids), veterinary drug residues (e.g., antibiotics, hormones), heavy metals (e.g., lead, cadmium, arsenic), mycotoxins (e.g., aflatoxins, ochratoxin A), and emerging pollutants (e.g., microplastics, PFAS). These contaminants pose significant risks to human health. The effective detection and quantification of these contaminants necessitates advanced sample preparation techniques, including QuEChERS (quick, easy, cheap, effective, rugged, and safe), solid-phase extraction (SPE), liquid–liquid extraction (LLE), dispersive solid phase extraction (DSPE), and pressurized liquid extraction (PLE), which are tailored to complex food matrices such as cereals, dairy products, meat, seafood, fruits, vegetables, and processed foods.

This Special Issue seeks high-quality research on innovative extraction methods, miniaturized and green analytical techniques, and state-of-the-art detection technologies—such as UHPLC-MS/MS and GC-MS/MS. We cordially invite studies that explore automated, high-throughput, and AI-assisted analytical workflows, as well as multiresidue methods that enhance food safety monitoring. By contributing to this Special Issue, researchers will engage in a dynamic exchange of knowledge, driving advancements in food contaminant analysis, regulatory compliance, and risk assessment. Contributions in the form of original research, reviews, and methodological breakthroughs that challenge the current boundaries of sensitivity, selectivity, and sustainability in food safety science are particularly encouraged. We cordially request the submission of manuscripts that will contribute to this pivotal scientific undertaking.

Prof. Dr. Osmar Damian Prestes
Prof. Dr. Renato Zanella
Guest Editors

Manuscript Submission Information

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Keywords

  • food safety
  • sample preparation
  • mass spectrometry techniques
  • chromatographic analysis

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Published Papers (1 paper)

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Research

14 pages, 1383 KB  
Article
Acidified Acetonitrile Extraction and Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry for Multiresidue Determination of 136 Pesticides in Tahiti Lime (Citrus latifolia)
by Karolaine da Silva Albarnaz, Juliana Diniz de Barros Kuntz, Luana Floriano, Franciele Fátima Machado, Martha Bohrer Adaime, Renato Zanella and Osmar Damian Prestes
Foods 2026, 15(17), 2967; https://doi.org/10.3390/foods15172967 - 24 Aug 2026
Abstract
The determination of pesticide residues in citrus fruits remains analytically challenging due to their high acidity and complex chemical compositions, which can compromise extraction efficiency and promote significant matrix effects, particularly for acidic compounds. In this study, an acidified acetonitrile-based QuEChERS method was [...] Read more.
The determination of pesticide residues in citrus fruits remains analytically challenging due to their high acidity and complex chemical compositions, which can compromise extraction efficiency and promote significant matrix effects, particularly for acidic compounds. In this study, an acidified acetonitrile-based QuEChERS method was developed and validated for the multiresidue determination of 136 pesticides in Tahiti lime (Citrus latifolia) using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC–MS/MS). The proposed approach employs 1% formic acid in acetonitrile and omits the conventional clean-up step, aiming to improve analyte recovery and analytical throughput. Method validation was performed according to SANTE guidelines, demonstrating satisfactory linearity (R2 ≥ 0.99 for all analytes), limits of quantification of 0.01 mg kg−1, and recoveries within 70–120%, with relative standard deviations ≤ 20% for the vast majority of compounds. Notably, the method achieved consistent and reliable performance for 12 acidic pesticides, which are typically problematic in conventional QuEChERS approaches. Application to 22 real samples revealed the presence of 14 pesticide residues, with some compounds exceeding European Union (EU) maximum residue limits. The proposed method provides a simple, efficient, and robust alternative for comprehensive pesticide monitoring in citrus fruits, with particular advantages for the determination of acidic compounds in highly complex matrices. Full article
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