Metabolic Fate of Food Bioactive Compounds in Humans

Dear Colleagues,

Bioactive compounds occurring mainly in vegetable foods are of particular interest for their therapeutical application. These dietary phytochemicals can access systemic circulation and reach target tissues in a manner that is strictly dependent on their bioaccessibility and bioavailability. Specifically, the latter condition generally affects their capacity to have a potential biological influence on health. Interest in the biological activities and resultant health benefits from phytochemical-rich foods has focused much scientific attention in the evaluation of factors that can modulate their bioavailability. Thus, a main goal is the identification of food parameters (macro- and micro-nutrients, physical form, phytochemical profile, etc.) and physiological aspects (digestion, absorption, metabolism, distribution, and excretion) that can affect bioavailability. An appropriate elucidation of these factors may help to plan strategies that can measure the bioavailability of dietary phytochemicals and lead to its optimization in favor of the best beneficial effects on human health.

Prof. Dr. Gian Carlo Tenore
Dr. Maria Maisto
Guest Editors

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