Biological Potential of Antioxidant Compounds from Vegetable Sources—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1715

Special Issue Editors


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Department of Excellence of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: organic chemistry; analytical chemistry; antivirals; nutraceuticals; food chemistry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Excellence of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: cosmetics; transdermal absorption; nutricosmetics; skin analysis; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In view of the great response that we received to the previous Special Issue "Biological Potential of Antioxidant Compounds from Vegetable Sources", we decided to revisit this topic.

In recent decades, it has been established that oxidative stress plays a pivotal role in the generation and progression of different pathological conditions, such as cardiovascular diseases, diabetes, neurodegenerative diseases and age-related disorders. Oxidative stress is defined as an imbalance between reactive oxygen and nitrogen species (ROS/RNS) production and the physiological human antioxidant defense. In this context, great attention has been paid to natural antioxidant compounds as natural human health-protecting agents.

It is well known that fruits and vegetables are the richest sources of reducing molecules and the most studied are phenolic compounds, carotenoids, vitamins, triterpenic acids and some minerals (e.g., selenium and zinc). Different cellular molecular mechanisms have been proposed, being limited not only to the evaluation of their radical scavenger and ferric reducing activities but also the positive regulation of transcriptional factors involved in the induction of antioxidant endogenous enzyme expression.

In this Special Issue, we invite researchers to provide original research articles, clinical reports and review articles related to every type of natural antioxidant. We are waiting for articles from researchers in a wide range of fields such as food chemistry, cosmetics, medicine, nutrition and biochemistry. We want this Special Issue to provide a valuable collection of new knowledge in this field.

Dr. Maria Maisto
Prof. Dr. Vincenzo Summa
Prof. Dr. Gian Carlo Tenore
Dr. Ritamaria Di Lorenzo
Guest Editors

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Keywords

  • reducing compounds
  • oxidative stress
  • natural sources
  • antioxidant activity
  • cellular damage

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Published Papers (2 papers)

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Research

23 pages, 2493 KiB  
Article
Bioactive Compounds, Antioxidant, and Antimicrobial Activity of Seeds and Mucilage of Non-Traditional Cocoas
by Elena Coyago-Cruz, Iván Salazar, Aida Guachamin, Melany Alomoto, Marco Cerna, Gabriela Mendez, Jorge Heredia-Moya and Edwin Vera
Antioxidants 2025, 14(3), 299; https://doi.org/10.3390/antiox14030299 - 28 Feb 2025
Cited by 1 | Viewed by 788
Abstract
The biodiversity of the Amazon rainforest includes little-known cocoa species, which are essential resources for local communities. This study evaluated the bioactive compounds and antioxidant and antimicrobial activity of seeds and mucilage of four non-traditional cocoa species (Theobroma subincanum, T. speciosum [...] Read more.
The biodiversity of the Amazon rainforest includes little-known cocoa species, which are essential resources for local communities. This study evaluated the bioactive compounds and antioxidant and antimicrobial activity of seeds and mucilage of four non-traditional cocoa species (Theobroma subincanum, T. speciosum, T. bicolor and Herrania nitida). Physico-chemical properties, minerals, vitamin C, organic acids, phenolics, and carotenoids were analysed by spectrophotometric and chromatographic techniques. The antioxidant activity was measured by ABTS and DPPH, along with the antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus mutans, as well as Candida albicans and Candida tropicalis. T. subincanum seeds scored high in titratable acidity, magnesium, sodium, syringic acid, chlorogenic acid, caffeic acid, rutin, and quercetin. In contrast, the mucilage scored high in calcium, m-coumaric acid, ferulic acid, kaempferol, quercetin glycoside, and antimicrobial activity against Streptococcus mutans. T. speciosum mucilage excelled in malic acid, tartaric acid, naringenin, and antioxidant capacity. T. bicolor seeds excelled in lutein and antimicrobial activity against Staphylococcus aureus and Candida albicans, and mucilage in iron, potassium, vitamin C, citric acid, gallic acid and 4-hydroxybenzoic acid, zeaxanthin, β-carotene, and antioxidant capacity by ABTS. The mucilage of H. nitida has a high soluble solids content. These results highlight the potential of these species as sustainable sources of functional compounds and nutraceuticals. Full article
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27 pages, 5107 KiB  
Article
Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction
by Ana Karina Aranda-Rivera, Isabel Amador-Martínez, Omar Emiliano Aparicio-Trejo, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Emma Saavedra, Fernando E. García-Arroyo, José Pedraza-Chaverri, Laura Gabriela Sánchez-Lozada and Edilia Tapia
Antioxidants 2025, 14(3), 288; https://doi.org/10.3390/antiox14030288 - 28 Feb 2025
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Abstract
Obstructive nephropathy (ON), characterized by urine flow disruption, can induce chronic kidney disease (CKD). Although the release of the obstruction is performed as the primary intervention, renal pathology often persists and progresses. Accordingly, the murine model of releasing unilateral ureteral obstruction (RUUO) is [...] Read more.
Obstructive nephropathy (ON), characterized by urine flow disruption, can induce chronic kidney disease (CKD). Although the release of the obstruction is performed as the primary intervention, renal pathology often persists and progresses. Accordingly, the murine model of releasing unilateral ureteral obstruction (RUUO) is valuable for investigating the molecular events underlying renal damage after obstruction release. Remarkably, after RUUO, disturbances such as oxidative stress, inflammation, lipid accumulation, and fibrosis continue to increase. Mitochondrial dysfunction contributes to fibrosis in the UUO model, but its role in RUUO remains unclear. Additionally, the impact of using antioxidants to restore mitochondrial function and prevent renal fibrosis in RUUO has not been determined. This study aimed to determine the therapeutic effect of pre-administering the antioxidant sulforaphane (SFN) in the RUUO model. SFN was administered 1 day before RUUO to evaluate mitochondrial biogenesis, fatty acids (FA) metabolism, bioenergetics, dynamics, and mitophagy/autophagy mechanisms in the kidney. Our data demonstrated that SFN enhanced mitochondrial biogenesis and reestablished mitochondrial oxygen consumption and β-oxidation. These effects collectively reduced lipid accumulation and normalized mitochondrial dynamics, mitophagy, and autophagy, thereby mitigating fibrosis after obstruction. Our findings suggest that SFN holds promise as a potential therapeutic agent in ON-induced CKD progression in RUUO and opens new avenues in studying antioxidant molecules to treat this disease. Full article
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