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Harnessing Nature’s Potential: Plant-Derived Substances for Controlling Appetite and Promoting Weight Management

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 1889

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Department of Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: antioxidants; nutraceuticals; phenolic compounds; anti-inflammatory potential; antidiabetic activity; enzyme inhibition
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Special Issue Information

Dear Colleagues,

Obesity is a globally prevalent chronic disease that increases risk factors of numerous pathological conditions, thereby representing one of the major health challenges of our time. In the face of rising obesity rates, there is an urgent need for effective weight management strategies. This Special Issue, titled “Harnessing Nature’s Potential: Plant-Derived Substances for Controlling Appetite and Promoting Weight Management”, focuses on evaluating the efficacy of plant-derived substances in regulating appetite and body weight. Moreover, it delves into the intricate interplay between phytochemicals and the human body, unraveling the molecular pathways in which these substances engage to modulate appetite, enhance satiety, and influence energy metabolism.

Contributions to this issue explore a range of bioactive compounds found in plants, such as polyphenols, alkaloids, and terpenes, elucidating their roles in appetite regulation and energy homeostasis. Key topics include the interaction of these compounds with hormonal and neural pathways controlling hunger and satiety, their impact on gut microbiota composition and function, and their influence on metabolic rate and fat oxidation.

Therefore, through rigorous research, including original articles, clinical trials and review articles, this issue aims to provide a comprehensive understanding of how plant-derived substances can be effectively utilized in managing appetite and promoting weight management, offering a promising avenue for the development of natural strategies in the fight against obesity and its associated health risks. This holistic approach will provide a critical assessment of the practical benefits and limitations of using plant-derived substances for health and nutrition.

This project was led by Prof. Dr. Ettore Novellino, Prof. Dr. Gian Carlo Tenore, Dr. Elisabetta Schiano and topical advisory panel member Dr. Fortuna Iannuzzo (University of Naples Federico II).

Prof. Dr. Gian Carlo Tenore
Prof. Dr. Ettore Novellino
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant-derived substances
  • obesity
  • satiety control
  • weight management
  • gut hormones
  • bioactive compounds
  • energy metabolism
  • phytochemicals
  • molecular mechanisms
  • clinical trials

Published Papers (1 paper)

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Research

14 pages, 846 KiB  
Article
Gengricin®: A Nutraceutical Formulation for Appetite Control and Therapeutic Weight Management in Adults Who Are Overweight/Obese
by Elisabetta Schiano, Fortuna Iannuzzo, Mariano Stornaiuolo, Fabrizia Guerra, Gian Carlo Tenore and Ettore Novellino
Int. J. Mol. Sci. 2024, 25(5), 2596; https://doi.org/10.3390/ijms25052596 - 23 Feb 2024
Cited by 1 | Viewed by 1251
Abstract
In the field of nutritional science and metabolic disorders, there is a growing interest in natural bitter compounds capable of interacting with bitter taste receptors (TAS2Rs) useful for obesity management and satiety control. This study aimed to evaluate the effect of a nutraceutical [...] Read more.
In the field of nutritional science and metabolic disorders, there is a growing interest in natural bitter compounds capable of interacting with bitter taste receptors (TAS2Rs) useful for obesity management and satiety control. This study aimed to evaluate the effect of a nutraceutical formulation containing a combination of molecules appropriately designed to simultaneously target and stimulate these receptors. Specifically, the effect on CCK release exerted by a multi-component nutraceutical formulation (Cinchona bark, Chicory, and Gentian roots in a 1:1:1 ratio, named Gengricin®) was investigated in a CaCo-2 cell line, in comparison with Cinchona alone. In addition, these nutraceutical formulations were tested through a 3-month randomized controlled trial (RCT) conducted in subjects who were overweight–obese following a hypocaloric diet. Interestingly, the Gengricin® group exhibited a significant greater weight loss and improvement in body composition than the Placebo and Cinchona groups, indicating its effectiveness in promoting weight regulation. Additionally, the Gengricin® group reported higher satiety levels and a significant increase in serum CCK levels, suggesting a physiological basis for the observed effects on appetite control. Overall, these findings highlight the potential of natural nutraceutical strategies based on the combination of bitter compounds in modulating gut hormone release for effective appetite control and weight management. Full article
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