Functional Foods and Nutraceuticals in the Prevention of Noncommunicable Chronic Diseases

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 3494

Special Issue Editors


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Guest Editor
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
Interests: functional foods and nutraceuticals in the prevention of chronic diseases; particularly coronary artery disease and diabetes

E-Mail Website
Guest Editor
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
Interests: host–pathogen–environment interactions; microbiome; antimicrobials and antimicrobial adjuvants; functional foods and nutraceuticals; immune regulation

Special Issue Information

Dear Colleagues,

Noncommunicable chronic diseases, such as cardiovascular diseases, cancer, diabetes, chronic respiratory diseases, and non-alcoholic fatty liver disease (NAFLD), represent a significant global health challenge, accounting for a substantial proportion of morbidity, mortality, and healthcare costs. These conditions are influenced by a combination of genetic, lifestyle, and environmental factors. Although most chronic diseases can be managed using conventional therapeutic agents, the safety and potential side effects of these agents represent a major concern for many patients.

Functional foods and nutraceuticals are rich sources of bioactive compounds, including flavonoids, carotenoids, polyphenols, phytosterols, and probiotics, that offer a number of health-promoting effects, including anti-inflammatory, antioxidant, and lipid-lowering effects, as well as other metabolic benefits. Moreover, these naturally derived products are generally regarded as safe, leading to growing interest in their use as alternatives or adjuncts in the management and prevention of noncommunicable chronic diseases. There has been significant interest from the general population, patients, and healthcare professionals in the application of these natural products, propelling growth in this industry. The global market value of this industry was estimated to be approximately USD 258 billion in 2021, and this is projected to increase to USD 530 billion by the year 2028, according to a recent review in Foods (Foods. 2023 Nov; 12(21): 4001). In the last three years, scientists and healthcare professionals have made significant contributions to this field, with 5479 publications, according to statistics from Web of Science. 

We are very excited to announce the launch of our Special Issue, entitled "Functional Foods and Nutraceuticals in the Prevention of Noncommunicable Chronic Diseases". Within this broad context, we invite contributions (original research, mini-reviews, systematic reviews and meta-analyses, clinical trial reports, case studies, methods, and opinions) that explore the role of functional foods and nutraceuticals in the prevention and management of noncommunicable chronic diseases. We will process submissions in a fair and timely manner, making the selected contributions available to an online readership in high quality and with no restrictions. The publisher will ensure that all copyright is appropriately managed and protected. Furthermore, we are thrilled to announce that the publisher will consider special waiver requests from individuals who may not be able to fully cover the publication costs.

We look forward to receiving your submissions.

Prof. Dr. Mohammed Moghadasian
Dr. Juventus Aweya Jude
Guest Editors

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Keywords

  • functional foods
  • nutraceuticals
  • naturally derived products
  • noncommunicable chronic diseases
  • diabetes
  • cancer
  • cardiovascular diseases
  • phytochemicals
  • probiotics
  • prebiotics
  • bioprospecting
  • novel foods
  • designer foods
  • healthy foods
  • health promotion
  • disease prevention and management

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Published Papers (2 papers)

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Research

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21 pages, 7918 KiB  
Article
Genotoxic and Anti-Genotoxic Assessments of Fermented Houttuynia cordata Thunb. Leaf Ethanolic Extract and Its Anti-Cancer Effect in a Dual-Organ Carcinogenesis Model of Colon and Liver in Rats
by Chonikarn Singai, Pornsiri Pitchakarn, Sirinya Taya, Rawiwan Wongpoomchai and Ariyaphong Wongnoppavich
Foods 2024, 13(22), 3645; https://doi.org/10.3390/foods13223645 - 15 Nov 2024
Viewed by 2424
Abstract
The incidence of multiple-organ cancers has recently increased due to simultaneous exposure to various environmental carcinogens. Houttuynia cordata Thunb. (H. cordata) is recognized for its many health benefits, including its anti-cancer properties. The fermentation of its leaves has been shown to [...] Read more.
The incidence of multiple-organ cancers has recently increased due to simultaneous exposure to various environmental carcinogens. Houttuynia cordata Thunb. (H. cordata) is recognized for its many health benefits, including its anti-cancer properties. The fermentation of its leaves has been shown to significantly enhance the bioflavonoid content and its bioactivities. This study aimed to evaluate the effectiveness of fermented H.cordata leaf (FHCL) extracts against combined carcinogens and investigate the underlying mechanisms. The crude ethanolic extract of FHCL was partitioned to obtain hexane- (HEX), dichloromethane- (DCM), ethyl acetate- (ETAC), butanol- (nBA), and residue fractions. The crude ethanolic extract (200–250 μg/mL) and the DCM fraction (50 μg/mL) significantly reduced NO production in RAW264.7 macrophages. In addition, the crude extract and the DCM and ETAC fractions showed anti-genotoxicity against aflatoxin B1 and 2-amino-3,4-dimethylimidazo [4,5-f]quinoline (MeIQ) in Salmonella typhimurium assays (S9+). Despite demonstrating genotoxicity in the Salmonella mutation assay (with and without S9 activation), oral administration of the crude extract at 500 mg/kg of body weight (bw) for 40 days in rats did not induce micronucleated hepatocytes, indicating that the extract is non-genotoxic in vivo. Moreover, the crude extract significantly decreased Phase I but increased Phase II xenobiotic-metabolizing enzyme activities in the rats. Next, the anti-cancer effects of FHCL were evaluated in a dual-organ carcinogenesis model of the colon and liver in rats induced by 1,2-dimethylhydrazine (DMH) and diethylnitrosamine (DEN), respectively. The crude extract significantly reduced not only the number and size of glutathione S-transferase placental form positive foci in the liver (at doses of 100 and 500 mg/kg bw) but also the number of aberrant crypt foci in rat colons (at 500 mg/kg bw). Furthermore, FHCL significantly reduced the expression of proliferating cell nuclear antigen (PCNA) in the colon (at 100 and 500 mg/kg bw) and liver (at 500 mg/kg bw) of the treated rats. In conclusion, FHCL exhibits significant preventive properties against colon and liver cancers in this dual-organ carcinogenesis model. Its mechanisms of action may involve anti-inflammatory effects, the prevention of genotoxicity, the modulation of xenobiotic-metabolizing enzymes, and the inhibition of cancer cell proliferation. These findings support the use of FHCL as a natural supplement for preventing cancer. Full article
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Review

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20 pages, 644 KiB  
Review
The Role of Diet and Nutrition in Cancer Development and Management: From Molecular Mechanisms to Personalized Interventions
by Maxim Ruban, Elizaveta Pozhidaeva, Larisa Bolotina and Andrey Kaprin
Foods 2025, 14(10), 1788; https://doi.org/10.3390/foods14101788 - 18 May 2025
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Abstract
Diet plays a crucial role in cancer development and progression, beyond traditional risk factors. This review aims to summarize current evidence on the role of diet and specific nutrients in cancer development and progression, focusing on molecular mechanisms. We also discuss the potential [...] Read more.
Diet plays a crucial role in cancer development and progression, beyond traditional risk factors. This review aims to summarize current evidence on the role of diet and specific nutrients in cancer development and progression, focusing on molecular mechanisms. We also discuss the potential of personalized dietary interventions, based on tumor and patient characteristics, in enhancing cancer prevention and treatment strategies. The review covers the impact of calories, protein, sugar, and other dietary components on signaling pathways and growth factors involved in carcinogenesis. We examine the influence of obesity, insulin resistance, and other metabolic factors on cancer risk and outcomes. The article also explores current dietary strategies, including calorie restriction, ketogenic diets, and the role of the gut microbiome in modulating response to anticancer therapies. Finally, we highlight the need for further research to develop targeted, personalized dietary recommendations based on an individual’s tumor profile, stage of disease, and other clinical factors. Integrating such personalized dietary approaches into cancer prevention and treatment holds promise for improving patient outcomes and quality of life. Full article
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