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Fishes
Special Issues
Genetic Foundations of Disease Resistance in Fishes
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Genetic Foundations of Disease Resistance in Fishes

A special issue of Fishes (ISSN 2410-3888). This special issue belongs to the section "Genetics and Biotechnology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 541

Editor

Dr. Yunji Xiu

E-Mail Website
Guest Editor
School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266237, China
Interests: fish immune genetics; disease resistance

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Genetic Foundations of Disease Resistance in Fishes”, aims to consolidate cutting‑edge research for sustainable aquaculture and fish health management. It addresses urgent global challenges from infectious diseases by revealing key genes, regulatory networks, and molecular mechanisms underlying resistance/susceptibility. We welcome original research, reviews, and short communications covering QTL mapping, GWAS, transcriptomics, epigenetics, genome editing, and selective breeding for disease‑resistant strains.

By integrating findings across farmed and wild fish species, this Special Issue fills critical gaps in the current literature, linking genetic architecture to immune function and disease outcomes. It complements existing studies by emphasizing cross‑species comparability, mechanistic validation, and translational applications for breeding and health intervention.

Dr. Yunji Xiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fishes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • disease resistance
  • fish genetics
  • QTL
  • GWAS
  • immune genetics
  • genomic selection
  • aquaculture breeding

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

15 pages, 1153 KB  
Article
Development of SNP Markers and Their Association with MSRV Resistance in Largemouth Bass (Micropterus salmoides)
by Weimeng Wang, Di Qiao, Junjie Zhu, Zhihua Zhang, Xiaoming Shen and Guofu Lu
Fishes 2026, 11(7), 382; https://doi.org/10.3390/fishes11070382 - 25 Jun 2026
Viewed by 138
Abstract
The present study investigated the association between single-nucleotide polymorphisms (SNPs) and resistance to Micropterus salmoides rhabdovirus (MSRV) in largemouth bass. Candidate SNPs were first screened from transcriptome sequencing data and subsequently validated, resulting in 37SNP sites with good PCR amplification performance. Genotyping was [...] Read more.
The present study investigated the association between single-nucleotide polymorphisms (SNPs) and resistance to Micropterus salmoides rhabdovirus (MSRV) in largemouth bass. Candidate SNPs were first screened from transcriptome sequencing data and subsequently validated, resulting in 37SNP sites with good PCR amplification performance. Genotyping was performed using high-resolution melting (HRM) analysis, and associations between SNP loci and MSRV resistance were assessed using the chi-square test. Transcriptome analysis further elucidated immune-related pathways activated in response to MSRV infection. Among the tested loci, after Bonferroni correction, four SNPs remained highly significant (p < 0.001) and three became suggestive (p < 0.05). These markers provide valuable resources for marker-assisted selection in largemouth bass breeding programs and contribute to the development of disease-resistant strains. Full article
(This article belongs to the Special Issue Genetic Foundations of Disease Resistance in Fishes)
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16 pages, 16340 KB  
Article
Time-Series Transcriptomics of a Gill Cell Line (BTG) from Chinese Bahaba (Bahaba taipingensis) During ISKNV Infection (3–24 hpi)
by Chenfei Guo, Zhihong Gong, Fei Fang, Xihong Li, Lei Wang, Na Wang, Zhangfan Chen, Lin Yan, Kuoqiu Yan, Guobin Hu and Songlin Chen
Fishes 2026, 11(6), 352; https://doi.org/10.3390/fishes11060352 - 15 Jun 2026
Viewed by 208
Abstract
The Chinese bahaba (Bahaba taipingensis), an endangered marine fish, is highly vulnerable to infectious spleen and kidney necrosis virus (ISKNV). In this work, we developed a gill filament-derived cell line, designated BTG, to investigate how these cells respond to ISKNV over [...] Read more.
The Chinese bahaba (Bahaba taipingensis), an endangered marine fish, is highly vulnerable to infectious spleen and kidney necrosis virus (ISKNV). In this work, we developed a gill filament-derived cell line, designated BTG, to investigate how these cells respond to ISKNV over time, specifically from 3 to 24 h post-infection (hpi). BTG cells grew steadily, displayed a diploid chromosome number of 2n = 48, demonstrated high transfection efficiency, and were highly susceptible to viral infection. Characteristic cytopathic effects (CPEs) became noticeable as early as 6 hpi at 27 °C. RNA-seq profiling showed that the number of differentially expressed genes (DEGs) steadily increased with time. Standard enrichment analysis at individual time points (3, 6, 12, and 24 hpi) highlighted pathways mainly involved in DNA replication, cell cycle control, ribosome assembly, transcription and translation, mismatch repair, and cell adhesion. Temporal clustering analysis, however, revealed hidden patterns in immune gene expression. Genes that were consistently downregulated were enriched in immune-related pathways, including ECM–receptor interaction, cytokine–receptor signaling, PI3K–AKT, and Wnt signaling, indicating prolonged suppression of host defense mechanisms. In contrast, clusters of genes transiently upregulated during the first 6 h post-infection were associated with antiviral and innate immune pathways, such as NF-κB, JNK, IRF3, IRF7, caspases, JAK, MHC I, and lysosome-related functions, suggesting a rapid but short-lived antiviral response. Genes that were continuously upregulated were primarily involved in nucleic acid replication and protein synthesis, reflecting a gradual host cell reprogramming to support viral replication. Taken together, these findings reveal a temporal shift in BTG cells from an initial burst of immune activity to immune suppression, accompanied by enhanced viral replication. The BTG cell line thus represents a valuable in vitro model for dissecting ISKNV–host interactions and offers new perspectives on the molecular strategies employed by megalocytiviruses in B. taipingensis. Full article
(This article belongs to the Special Issue Genetic Foundations of Disease Resistance in Fishes)
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