Health Benefits of Lactic Acid Bacteria: Gut Microbiota and Beyond

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Probiotic Strains and Fermentation".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 3754

Special Issue Editor


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Guest Editor
Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
Interests: food microbiology; fermentation; applied microbiology; molecular microbiology; food and nutrition; lactic acid bacteria; gut microbiota; cell biology; molecular cell biology; microbial molecular biology; host–microbe interactions

Special Issue Information

Dear Colleagues,

Lactic acid bacteria (LAB) are a widespread group of bacteria, traditionally associated with food fermentation, that have drawn great attention for their several beneficial properties. Probiotic LAB and/or LAB-driven fermented foods can exert a wide range of positive effects on human health by direct action and/or by production of a broad spectrum of bioactive metabolites (i.e., organic acids, SCFAs, exopolysaccharides, bacteriocin, vitamins, γ-aminobutyric acid, etc.). Once ingested, LAB can reach the gut and transiently colonize it and interact with the resident microbiota, whose perturbation has been strictly linked with various diseases. Intake of LAB and/or LAB-driven fermented foods has been associated with the modulation of gut microbiome structure and composition, protection against pathogens, immunomodulation as well as maintenance of gut homeostasis and intestinal barrier integrity, resulting in the prevention and/or amelioration of gut inflammation and other intestinal or systemic disease, including neurodevelopment and neurodegenerative disorders.

However, the precise biological mechanism and effective efficacy remain unclear; thus, this Special Issue will welcome in vitro, in vivo, and clinical studies that deepen our knowledge of the health benefits and efficacy of LAB and/or LAB-driven fermented foods.

Review articles regarding the above topics will also be taken into consideration.

Dr. Roberta Prete
Guest Editor

Manuscript Submission Information

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Keywords

  • lactic acid bacteria
  • lactobacilli
  • probiotics
  • postbiotics
  • bioactive metabolites
  • neurotransmitters
  • gut microbiota
  • health benefits
  • fermented foods
  • functional foods

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Published Papers (1 paper)

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19 pages, 2237 KiB  
Systematic Review
Probiotic SYNBIO® Blend’s Impact on Constipation in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Maria Magdalena Coman, Nadaniela Egidi, Stefania Silvi, Renato De Leone and Maria Cristina Verdenelli
Fermentation 2024, 10(10), 518; https://doi.org/10.3390/fermentation10100518 - 12 Oct 2024
Viewed by 2664
Abstract
Aims: Research on probiotics for constipation management is still growing, and plays a crucial role in the definition of a management strategy for bowel wellbeing, constipation, and related outcomes. The present systematic review and meta-analysis of the beneficial effects of the SYNBIO® [...] Read more.
Aims: Research on probiotics for constipation management is still growing, and plays a crucial role in the definition of a management strategy for bowel wellbeing, constipation, and related outcomes. The present systematic review and meta-analysis of the beneficial effects of the SYNBIO® blend, to consolidate the data from various clinical trials, was conducted. Methods: A literature search using PubMed, Web of Science, and Google Scholar databases was conducted. The search was limited to clinical trials that used the SYNBIO® blend, either as dietary supplements or probiotic-enriched foods. Independently, two reviewers evaluated the trial’s quality and extracted all data. A 95% confidence interval (CI) of a weighted mean difference (MD) was used to pool continuous data. For the analysis, Review Manager version 5.4 was used. Results: Seven clinical trials involving a total of 1095 subjects were included in the analysis. Overall, the SYNBIO® blend significantly improved constipation relief by 0.75 (95% CI: 0.31 to 1.19; p = 0.0008) in 52% of the subjects, and significantly increased intestinal regularity by 1.90 compared to the placebo (95% CI: 1.02 to 2.78; p < 0.0001) in more than 60% of individuals. No adverse events were reported. Conclusions: The SYNBIO® blend was found to significantly improve overall constipation, intestinal regularity, abdominal pain, and intestinal cramping. This suggests that people with these specific symptoms could benefit from this probiotic combination. Full article
(This article belongs to the Special Issue Health Benefits of Lactic Acid Bacteria: Gut Microbiota and Beyond)
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