Risk of Type 2 Diabetes Mellitus: Cardiorenometabolic Syndrome and Its Components

A special issue of Diabetology (ISSN 2673-4540).

Deadline for manuscript submissions: closed (1 May 2024) | Viewed by 575

Special Issue Editors


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Guest Editor
1. Department of Clinical Pharmacology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia
2. Department of Basic and Clinical Pharmacology with Toxicology, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia
Interests: clinical pharmacology; diabetes; evidence-based medicine; metabolic syndrome; obesity
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department for Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Interests: nephrology; cardiovascular risk; arterial hypertension

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Guest Editor Assistant
Department of Endocrinology, Internal Clinic, University Hospital Center Zagreb, Zagreb, Croatia
Interests: obesity; diabetes type 2; metabolic syndrome

Special Issue Information

Dear Colleagues,

Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension. If left untreated, MetS is significantly associated with an increased risk of developing diabetes and cardiovascular diseases (CVDs). Given that the latter constitute by far the leading cause of morbidity and mortality worldwide, it has become essential to extensively investigate the role played by MetS in this context to reduce the heavy burden of the disease.

Bearing this in mind, A. Belančić, M. Matovinović and B. Jelaković are organizing and editing this Special Issue titled “Risk of Type 2 Diabetes Mellitus: Cardiorenometabolic Syndrome and Its Components”.

Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and the prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue “Risk of Type 2 Diabetes Mellitus: Cardiorenometabolic Syndrome and Its Components”, we aim to publish outstanding contributions in the key fields covered by the journal, which will make a great contribution to the community. The complete Special Issue will be published in book format after 10 papers have been published.

Thus, we believe that Diabetology is an excellent platform to support such an overview of current evidence and insights regarding cardiorenometabolic syndrome and its components that we are currently facing or that we will face soon.

We hope that our Special Issue will draw the attention of readers and clinicians in general.

If you would like to publish your article (that fits the scope of the aforementioned Special Issue) feel free to contact the editors or some of the Editorial Board Members of the Diabetology journal. We look forward to the potential collaboration.

Dr. Andrej Belančić
Prof. Dr. Bojan Jelaković
Guest Editors

Dr. Martina Matovinović
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diabetology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • diabetes
  • cardiovascular diseases

Published Papers (1 paper)

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Research

16 pages, 2147 KiB  
Article
Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular O-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells?
by Israel O. Bolanle, Gillian A. Durham, James P. Hobkirk, Mahmoud Loubani, Roger G. Sturmey and Timothy M. Palmer
Diabetology 2024, 5(2), 162-177; https://doi.org/10.3390/diabetology5020013 - 25 Apr 2024
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Abstract
Protein O-GlcNAcylation, a dynamic and reversible glucose-dependent post-translational modification of serine and threonine residues on target proteins, has been proposed to promote vascular smooth muscle cell proliferation and migration events implicated in vein graft failure (VGF). Therefore, targeting the enzymes (glutamine fructose-6P [...] Read more.
Protein O-GlcNAcylation, a dynamic and reversible glucose-dependent post-translational modification of serine and threonine residues on target proteins, has been proposed to promote vascular smooth muscle cell proliferation and migration events implicated in vein graft failure (VGF). Therefore, targeting the enzymes (glutamine fructose-6P amidotransferase (GFAT), O-GlcNAc transferase (OGT), and O-GlcNAcase (OGA)) that regulate cellular O-GlcNAcylation could offer therapeutic options to reduce neointimal hyperplasia and venous stenosis responsible for VGF. However, it is unclear how type 2 diabetes mellitus (T2DM) and hyperglycaemia affect the expression of these enzymes in human saphenous vein smooth muscle cells (HSVSMCs), a key cell type involved in the vascular dysfunction responsible for saphenous VGF. Therefore, our aim was to assess whether T2DM and hyperglycaemia affect GFAT, OGT, and OGA expression levels in HSVSMCs in vitro. Expression levels of GFAT, OGT, and OGA were determined in low-passage HSVSMCs from T2DM and non-T2DM patients, and in HSVSMCs treated for 48 h with hyperglycaemic (10 mM and 25 mM) glucose concentrations, by quantitative immunoblotting. Expression levels of OGT, OGA, and GFAT were not significantly different in HSVSMC lysates from T2DM patients versus non-T2DM controls. In addition, treatment with high glucose concentrations (10 mM and 25 mM) had no significant effect on the protein levels of these enzymes in HSVSMC lysates. From our findings, T2DM and hyperglycaemia do not significantly impact the expression levels of the O-GlcNAcylation-regulating enzymes OGT, OGA, and GFAT in HSVSMCs. This study provides a foundation for future studies to assess the role of O-GlcNAcylation on VGF in T2DM. Full article
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