Risk of Type 2 Diabetes Mellitus

The Special Issue “Risk of Type 2 Diabetes Mellitus: Cardiorenometabolic Syndrome and Its Components”, guest-edited by Dr. Andrej Belančić, Prof. Bojan Jelaković, and Dr. Martina Matovinović, explored the complex interrelationship between metabolic syndrome (MetS) and the global burden of type 2 diabetes mellitus (T2DM). This interdisciplinary collection examined how insulin resistance, dyslipidemia, central obesity, and hypertension—core components of MetS—converge to elevate the risk of T2DM and cardiovascular disease, the leading causes of morbidity and mortality worldwide. Published in Diabetology (ISSN 2673-4540), this Special Issue brought together high-quality original research articles, reviews, and communications addressing the biochemical, molecular, physiological, and clinical aspects of cardiorenometabolic syndrome. Topics included genetic susceptibility, pharmacogenetics, lifestyle interventions, diagnostic biomarkers, and emerging drug therapies, offering a comprehensive understanding of the mechanisms underlying metabolic-driven diabetes. Now compiled as a Reprint, this volume serves as a timely, authoritative resource for clinicians, researchers, and public health professionals. By synthesizing current knowledge and showcasing multidisciplinary insights, it aims to advance both clinical practice and scientific inquiry into T2DM prevention, early detection, and treatment. This Reprint stands as a valuable contribution to the ongoing efforts to mitigate the global impact of type 2 diabetes and its associated complications.