Role of Inflammation in Cancer
A Special Issue of Current Oncology (ISSN 1718-7729).
Deadline for manuscript submissions: 28 February 2027 | Viewed by 1147
Editor
Interests: cancer biology; inflammation; tumor microenvironment; acidosis; receptor signaling; GPCRs; targeted therapy; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is a hallmark of cancer. Chronic inflammation is associated with the development of various cancers. For example, chronic inflammation in the intestine (e.g., inflammatory bowel disease), stomach (e.g., Helicobacter pylori-induced gastritis) and liver (e.g., virus-induced hepatitis and steatohepatitis) is closely linked to the development of cancer in these organs. Moreover, obesity-related chronic inflammation increases the risk of developing numerous types of cancer. In the inflamed milieu, inflammatory cells generate cytokines, reactive oxygen/nitrogen species and pro-angiogenic factors that can induce DNA damage, gene mutations and promote cell proliferation and angiogenesis. Modulation of inflammation has been explored as a potential approach for cancer chemoprevention.
Immune cell infiltration is a common feature of solid tumors. The infiltrated tumor immune cells may have pro-inflammatory or anti-inflammatory functions. Recent development of immunotherapy, such as immune checkpoint inhibitors and immune cell therapies, has changed the paradigm of cancer treatment and improved survival in a subset of cancer patients. However, immunotherapy may also cause a broad spectrum of inflammatory and autoimmune side effects (e.g., dermatitis, pneumonitis, colitis and thyroiditis), known as immune-related adverse events. New strategies are needed to enhance the efficacy of cancer immunotherapy and reduce inflammatory and autoimmune side effects.
This Special Issue will cover research topics on inflammation and cancer, as indicated by, but not limited to, the keywords below. Original research papers, reviews, systematic review and commentaries are all welcome.
You may choose our Joint Special Issue in Cancers.
Prof. Dr. Li Yang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- inflammation
- immune cells
- cytokines
- anti-inflammatory
- tumor microenvironment
- immunotherapy
- immune-related adverse events
- targeted therapy
- chemotherapy and chemoprevention
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