Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "Tumor Microenvironment and Metabolism"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2016).
Prof. Dr. Li Yang Website E-Mail
Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
Interests: cancer biology; tumor microenvironment; inflammation; vascular biology; acidosis; pH sensing; G protein-coupled receptor; signal transduction
The tumor microenvironment has characteristic features of hypoxia, acidosis, nutrient deprivation, and high interstitial fluid pressure. In the process of tumor development and progression, the interactions between cancer cells and their microenvironment follow the principles of Darwinian selection, helping shape the somatic evolution of cancer cells. The biochemical features of the tumor microenvironment, including hypoxia, acidosis, and nutrient deprivation, also significantly regulate cancer cell metabolism, in which increased aerobic glycolysis (Warburg effect) is commonly observed. Reciprocally, deregulated cancer cell metabolism leads to accumulation of metabolic by-products, such as lactate and protons, in a tumor, which substantially modulate the tumor microenvironment. In addition to the effects on cancer cells, the tumor microenvironment also impacts the function of other cell types, including endothelial cells, immune cells, and fibroblasts in a tumor. Further understanding of the tumor microenvironment and metabolism will be advantageous for a comprehensive view of cancer biology and the improvement of cancer therapy.
This Special Issue will cover research topics on the tumor microenvironment, cancer cell metabolism, and the implications in cancer therapy, as indicated, but not limited, by the keywords below. Original research papers, review articles, theories, hypotheses, and commentaries are all welcome.
Assoc. Prof. Dr. Li Yang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor microenvironment
- cancer cell metabolism
- nutrient deprivation