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Current Oncology
Special Issues
Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer
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Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 18156

Special Issue Editor

Dr. Shinji Tanaka

E-Mail Website
Guest Editor
Department of Endoscopy, Hiroshima University Hospital, Hiroshima 734-8551, Japan
Interests: colorectal cancer; colorectal neoplasia; colonoscopy; magnifying colonoscopy; image-enhanced endoscopy; EUS; polypectomy; endoscopic mucosal resection; endoscopic submucosal dissection; lymph node metastasis; metastasis; recurrence

Special Issue Information

Dear Colleagues,

Thanks to the recent progress in endoscopic diagnosis and treatment, such as magnifying colonoscopy with image-enhanced endoscopy and endoscopic submucosal dissection, endoscopic treatment of gastrointestinal cancer has been gradually expanding. Further, as evidenced by detailed histopathologic and molecular pathologic examination, the number of gastrointestinal cancer cases with a positive outcome following endoscopic treatment has been growing. The aim of this Special Issue is to provide an overview of and summarize the progress of endoscopic diagnosis and treatment in recent years and discuss future perspectives. 

Dr. Shinji Tanaka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endoscopic diagnosis
  • endoscopic treatment
  • gastrointestinal cancer

Published Papers (6 papers)

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Research

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11 pages, 856 KiB  
Article
Should Laparoscopic Complete Mesocolic Excision Be Offered to Elderly Patients to Treat Right-Sided Colon Cancer?
by Michele Mazzola, Lorenzo Ripamonti, Alessandro Giani, Pietro Carnevali, Matteo Origi, BrunocDomenico Alampi, Irene Giusti, Pietro Achilli, Camillo Leonardo Bertoglio, Carmelo Magistro and Giovanni Ferrari
Curr. Oncol. 2023, 30(5), 4979-4989; https://doi.org/10.3390/curroncol30050376 - 13 May 2023
Viewed by 1370
Abstract
Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). Methods: Data [...] Read more.
Background: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). Methods: Data of patients undergoing laparoscopic right colectomies with CME for RCC between 2015 and 2018 were retrospectively analyzed. Selected patients were divided into two groups: the under-80 group and the over-80 group. Surgical, pathological, and oncological outcomes among the groups were compared. Results: A total of 130 patients were selected (95 in the under-80 group and 35 in the over-80 group). No difference was found between the groups in terms of postoperative outcomes, except for median length of stay and adjuvant chemotherapy received, which were in favor of the under-80 group (5 vs. 8 days, p < 0.001 and 26.3% vs. 2.9%, p = 0.003, respectively). No difference between the groups was found regarding overall survival and disease free survival. Using multivariate analysis, only the ASA score > 2 (p = 0.01) was an independent predictor of overall complications. Conclusions: laparoscopic right colectomy with CME for RCC was safely performed in elderly patients ensuring similar oncological outcomes compared to younger patients. Full article
(This article belongs to the Special Issue Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer)
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11 pages, 1099 KiB  
Article
Impact of Salvage Surgery following Colonic Endoscopic Polypectomy for Patients with Invasive Neoplasia
by Xiangzhou Tan, Markus Quante, Zihua Chen, Zhikang Chen, Alfred Königsrainer and Dörte Wichmann
Curr. Oncol. 2022, 29(5), 3138-3148; https://doi.org/10.3390/curroncol29050255 - 29 Apr 2022
Viewed by 1724
Abstract
Background: Invasive neoplasia (Tis-T1) are increasingly being encountered in the daily routine of endoscopic polypectomy. However, the need for salvage surgery following endoscopic therapy for invasive neoplasia is controversially discussed. Patients and Methods: Patients with endoscopic removal of invasive neoplasia were identified from [...] Read more.
Background: Invasive neoplasia (Tis-T1) are increasingly being encountered in the daily routine of endoscopic polypectomy. However, the need for salvage surgery following endoscopic therapy for invasive neoplasia is controversially discussed. Patients and Methods: Patients with endoscopic removal of invasive neoplasia were identified from the national Surveillance Epidemiology and End Results (SEER) Database 2005 to 2015. Survival analysis and Cox proportional hazard regression analysis in cancer-specific mortality and overall survival rate was used, which were stratified by T stage and polyp size. Results: A total of 5805 patients with endoscopic removal of invasive neoplasia were included in the analysis, of whom 1214 (20.9%) underwent endoscopic treatment alone and 4591 (79.1%) underwent endoscopic resection plus surgery. The survival analysis revealed that patients undergoing salvage surgery had a significantly better cancer-specific survival (97.4% vs. 95.8%, p-value = 0.017). In patients with T1 stage, additional salvage surgery led to a significantly higher cancer-specific survival (92.1% vs. 95.0%, p value = 0.047). Conclusion: Salvage surgery following endoscopic polypectomy may improve the oncological survival of patients with invasive neoplasia, especially in patients with T1 stage. Furthermore, the T stage, size, and localization of polyps, as well as the level of CEA, could be identified as significant predictors for lymphonodal and distant metastases. Full article
(This article belongs to the Special Issue Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer)
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Review

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22 pages, 2720 KiB  
Review
Extended Lymphadenectomy for Gastric Cancer in the Neoadjuvant Era: Current Status, Clinical Implications and Contentious Issues
by Luigi Marano, Ludovico Carbone, Gianmario Edoardo Poto, Valeria Restaino, Stefania Angela Piccioni, Luigi Verre, Franco Roviello and Daniele Marrelli
Curr. Oncol. 2023, 30(1), 875-896; https://doi.org/10.3390/curroncol30010067 - 08 Jan 2023
Cited by 9 | Viewed by 2671
Abstract
Despite its decreasing incidence, gastric cancer remains an important global healthcare problem due to its overall high prevalence and high mortality rate. Since the MAGIC and FNLCC/FFCD trials, the neoadjuvant chemotherapy has been recommended throughout Europe in gastric cancer. Potential benefits of preoperative [...] Read more.
Despite its decreasing incidence, gastric cancer remains an important global healthcare problem due to its overall high prevalence and high mortality rate. Since the MAGIC and FNLCC/FFCD trials, the neoadjuvant chemotherapy has been recommended throughout Europe in gastric cancer. Potential benefits of preoperative treatments include a higher rate of R0 resection achieved by downstaging the primary tumor, a likely effect on micrometastases and isolated tumor cells in the lymph nodes, and, as a result, improved cancer-related survival. Nevertheless, distortion of anatomical planes of dissection, interstitial fibrosis, and sclerotic tissue changes may increase surgical difficulty. The collection of at least twenty-five lymph nodes after neoadjuvant therapy would seem to ensure removal of undetectable node metastasis and reduce the likelihood of locoregional recurrence. It is not what you take but what you leave behind that defines survival. Therefore, para-aortic lymph node dissection is safe and effective after neoadjuvant chemotherapy, in both therapeutic and prophylactic settings. In this review, the efficacy of adequate lymph node dissection, also in a neoadjuvant setting, has been investigated in the key studies conducted to date on the topic. Full article
(This article belongs to the Special Issue Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer)
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11 pages, 724 KiB  
Review
Endoscopic Treatment of Superficial Gastric Cancer: Present Status and Future
by Hiroyuki Hisada, Yoshiki Sakaguchi, Kaori Oshio, Satoru Mizutani, Hideki Nakagawa, Junichi Sato, Dai Kubota, Miho Obata, Rina Cho, Sayaka Nagao, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Seiichi Yakabi, Yu Takahashi, Naomi Kakushima, Yosuke Tsuji, Nobutake Yamamichi and Mitsuhiro Fujishiro
Curr. Oncol. 2022, 29(7), 4678-4688; https://doi.org/10.3390/curroncol29070371 - 04 Jul 2022
Cited by 4 | Viewed by 6421
Abstract
Although the mortality rates of gastric cancer (GC) are gradually declining, gastric cancer is still the fourth leading cause of cancer-related death worldwide. This may be due to the high rate of patients who are diagnosed with GC at advanced stages. However, in [...] Read more.
Although the mortality rates of gastric cancer (GC) are gradually declining, gastric cancer is still the fourth leading cause of cancer-related death worldwide. This may be due to the high rate of patients who are diagnosed with GC at advanced stages. However, in countries such as Japan with endoscopic screening systems, more than half of GCs are discovered at an early stage, enabling endoscopic resection (ER). Especially after the introduction of endoscopic submucosal dissection (ESD) in Japan around 2000, a high en bloc resection rate allowing pathological assessment of margin and depth has become possible. While ER is a diagnostic method of treatment and may not always be curative, it is widely accepted as standard treatment because it is less invasive than surgery and can provide an accurate diagnosis for deciding whether additional surgery is necessary. The curability of ER is currently assessed by the completeness of primary tumor removal and the possibility of lymph node metastasis. This review introduces methods, indications, and curability criteria for ER of EGC. Despite recent advances, several problems remain unsolved. This review will also outline the latest evidence concerning future issues. Full article
(This article belongs to the Special Issue Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer)
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Other

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10 pages, 447 KiB  
Opinion
Issues and Prospects of Current Endoscopic Treatment Strategy for Superficial Non-Ampullary Duodenal Epithelial Tumors
by Tetsuya Suwa, Masao Yoshida and Hiroyuki Ono
Curr. Oncol. 2022, 29(10), 6816-6825; https://doi.org/10.3390/curroncol29100537 - 22 Sep 2022
Cited by 2 | Viewed by 1682
Abstract
An increasing number of duodenal tumors are being diagnosed over the years, leading to increased confusion regarding the choice of treatment options. Small-to-large tumors and histological types vary from adenoma to carcinoma, and treatment methods may need to be selected according to lesion [...] Read more.
An increasing number of duodenal tumors are being diagnosed over the years, leading to increased confusion regarding the choice of treatment options. Small-to-large tumors and histological types vary from adenoma to carcinoma, and treatment methods may need to be selected according to lesion characteristics. Because of its anatomic characteristics, complications are more likely to occur in the duodenum than in other gastrointestinal organs. Several reports have described the outcomes of conventional endoscopic mucosal resection, endoscopic submucosal dissection, cold snare polypectomy, underwater endoscopic mucosal resection, endoscopic full-thickness resection, and laparoscopic and endoscopic cooperative surgery for duodenal tumors. However, even in the guidelines set out by various countries, only the treatment methods are listed, and no clear treatment strategies are provided. Although there are few reports with a sufficiently high level of evidence, considering the currently available treatment options is essential. In this report, we reviewed previous reports on each treatment strategy, discussed the current issues and prospects, and proposed the best possible treatment strategy. Full article
(This article belongs to the Special Issue Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer)
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10 pages, 57319 KiB  
Opinion
Endoscopic Diagnosis and Treatment of Superficial Esophageal Squamous Cell Cancer: Present Status and Future Perspectives
by Ryu Ishihara
Curr. Oncol. 2022, 29(2), 534-543; https://doi.org/10.3390/curroncol29020048 - 26 Jan 2022
Cited by 4 | Viewed by 3471
Abstract
This review provides information regarding the preoperative examinations, indications for endoscopic resection (ER), and curability assessment in subjects with superficial esophageal squamous cell carcinoma (SCC). Narrow-band imaging (NBI) is a more sensitive modality for detecting esophageal cancer than conventional observation, and esophageal observation [...] Read more.
This review provides information regarding the preoperative examinations, indications for endoscopic resection (ER), and curability assessment in subjects with superficial esophageal squamous cell carcinoma (SCC). Narrow-band imaging (NBI) is a more sensitive modality for detecting esophageal cancer than conventional observation, and esophageal observation using NBI is thus recommended for the detection of superficial esophageal cancer. It is also important to adjust the volume of air in the esophagus during observation. Workup by non-magnifying followed by magnifying endoscopy is a common process for diagnosing the invasion depth of superficial esophageal SCCs in Japan. Endoscopic ultrasonography carries a risk of overdiagnosis, and its routine use is therefore not recommended. The Japanese endoscopic submucosal dissection/endoscopic mucosal resection guidelines for esophageal cancer considered the indications for ER based on the results of studies focusing on clinical MM/SM1 cancers, and concluded that clinical MM/SM1 carcinomas, except circumferential carcinoma, were an indication for ER. The curative effect of ER should be assessed based on histologic examination of the resected specimens. ER should be conducted based on a thorough understanding of the preoperative diagnosis, indication, curability, and additional treatment of esophageal SCC. Full article
(This article belongs to the Special Issue Endoscopic Diagnosis and Treatment of Gastrointestinal Cancer)
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