Special Issue "Recent Advances in Diagnosis and Treatment of Neuroblastoma"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Oncology and Hematology".

Deadline for manuscript submissions: closed (1 July 2018)

Special Issue Editor

Guest Editor
Dr. Navin Pinto

Seattle Children’s Hospital, 4800 Sand Point Way NE, M/S MB8.501, Seattle, WA 98105, USA
E-Mail
Interests: neuroblastoma; precision medicine; cancer immunotherapy

Special Issue Information

Dear Colleagues,

Neuroblastoma is a tumor marked by wide biologic variability and is disproportionately represented in childhood cancer deaths. This Special Issue will highlight recent advances in our understanding of the biologic basis of various neuroblastoma subtypes, recent improvements in the standard of care treatment of high-risk neuroblastoma and spotlight exciting new therapies for patients with relasped and refractory neuroblastoma.

Dr. Navin Pinto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • Neuroblastoma
  • cancer immunotherapy
  • MYCN
  • ALK
  • alternative lengthening of telomeres (ALT)
  • circulating tumor cells
  • cellular immunotherapy
  • MIBG therapy

Published Papers (3 papers)

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Review

Open AccessReview Genetic Predisposition to Neuroblastoma
Children 2018, 5(9), 119; https://doi.org/10.3390/children5090119
Received: 16 July 2018 / Revised: 22 August 2018 / Accepted: 28 August 2018 / Published: 31 August 2018
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Abstract
Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis. While neuroblastoma accounts for approximately 5% of all cancer diagnoses
[...] Read more.
Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis. While neuroblastoma accounts for approximately 5% of all cancer diagnoses in pediatrics, it disproportionately results in about 9% of all childhood deaths. Research advances over the decades have led to an improved understanding of neuroblastoma biology. However, the initiating events that lead to the development of neuroblastoma remain to be fully elucidated. It has only been recently that advances in genetics and genomics have allowed researchers to unravel the predisposing factors enabling the development of neuroblastoma and fully appreciate the interplay between the genetics of tumor and host. In this review, we outline the current understanding of familial neuroblastoma and highlight germline variations that predispose children to sporadic disease. We also discuss promising future directions in neuroblastoma genomic research and potential clinical applications for these advances. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
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Open AccessReview High-Risk Neuroblastoma Treatment Review
Children 2018, 5(9), 114; https://doi.org/10.3390/children5090114
Received: 30 June 2018 / Revised: 18 August 2018 / Accepted: 20 August 2018 / Published: 28 August 2018
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Abstract
Neuroblastoma is the most common extracranial solid tumor in children. One subset, high-risk neuroblastoma, is very difficult to treat and requires multi-modal therapy. Intensification of therapy has vastly improved survival rates, and research is focused on novel treatments to further improve survival rates.
[...] Read more.
Neuroblastoma is the most common extracranial solid tumor in children. One subset, high-risk neuroblastoma, is very difficult to treat and requires multi-modal therapy. Intensification of therapy has vastly improved survival rates, and research is focused on novel treatments to further improve survival rates. The current treatment schema is divided into three stages—induction, consolidation, and maintenance. This review serves as an overview of the current treatment for high-risk neuroblastoma and a glimpse at current research for future therapy. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
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Open AccessReview Late Effects and Survivorship Issues in Patients with Neuroblastoma
Children 2018, 5(8), 107; https://doi.org/10.3390/children5080107
Received: 29 June 2018 / Revised: 27 July 2018 / Accepted: 1 August 2018 / Published: 6 August 2018
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Abstract
Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a
[...] Read more.
Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma. Full article
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
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