Next Article in Journal
Delivering Pediatric Palliative Care: From Denial, Palliphobia, Pallilalia to Palliactive
Next Article in Special Issue
Molecularly Targeted Therapy for Neuroblastoma
Previous Article in Journal
Youth Physical Activity Patterns During School and Out-of-School Time
Previous Article in Special Issue
High-Risk Neuroblastoma Treatment Review
Review

Genetic Predisposition to Neuroblastoma

by 1,2 and 1,2,*
1
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
2
Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA
*
Author to whom correspondence should be addressed.
Children 2018, 5(9), 119; https://doi.org/10.3390/children5090119
Received: 16 July 2018 / Revised: 22 August 2018 / Accepted: 28 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis. While neuroblastoma accounts for approximately 5% of all cancer diagnoses in pediatrics, it disproportionately results in about 9% of all childhood deaths. Research advances over the decades have led to an improved understanding of neuroblastoma biology. However, the initiating events that lead to the development of neuroblastoma remain to be fully elucidated. It has only been recently that advances in genetics and genomics have allowed researchers to unravel the predisposing factors enabling the development of neuroblastoma and fully appreciate the interplay between the genetics of tumor and host. In this review, we outline the current understanding of familial neuroblastoma and highlight germline variations that predispose children to sporadic disease. We also discuss promising future directions in neuroblastoma genomic research and potential clinical applications for these advances. View Full-Text
Keywords: neuroblastoma; predisposition; germline; genome-wide association study (GWAS) neuroblastoma; predisposition; germline; genome-wide association study (GWAS)
Show Figures

Figure 1

MDPI and ACS Style

Barr, E.K.; Applebaum, M.A. Genetic Predisposition to Neuroblastoma. Children 2018, 5, 119. https://doi.org/10.3390/children5090119

AMA Style

Barr EK, Applebaum MA. Genetic Predisposition to Neuroblastoma. Children. 2018; 5(9):119. https://doi.org/10.3390/children5090119

Chicago/Turabian Style

Barr, Erin K., and Mark A. Applebaum. 2018. "Genetic Predisposition to Neuroblastoma" Children 5, no. 9: 119. https://doi.org/10.3390/children5090119

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop