Next Article in Journal
Pulmonary Metastasectomy in Pediatric Solid Tumors
Next Article in Special Issue
The Evolution of Risk Classification for Neuroblastoma
Previous Article in Journal
Chest Compressions in the Delivery Room
Previous Article in Special Issue
Novel Therapies for Relapsed and Refractory Neuroblastoma
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Children 2019, 6(1), 5;

Non-High-Risk Neuroblastoma: Classification and Achievements in Therapy

Center for Cancer and Blood Disorders, Children’s National Health System, The George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
Received: 3 December 2018 / Revised: 23 December 2018 / Accepted: 28 December 2018 / Published: 8 January 2019
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
PDF [205 KB, uploaded 8 January 2019]


Neuroblastoma, a tumor of the sympathetic nervous system, is the most common extra-cranial neoplasm of childhood. Variables with prognostic significance in patients with neuroblastoma, including age at diagnosis, disease stage, tumor histology, MYCN gene amplification, tumor cell ploidy, and the presence of segmental chromosomal aberrations are utilized to classify patients based on risk of disease recurrence. Patients with non-high-risk neuroblastoma, low- and intermediate-risk categories, represent nearly half of all newly diagnosed cases. This group has an excellent event-free and overall survival with current therapy. Over time, the objective in treatment of non-high-risk neuroblastoma has been reduction of therapy intensity to minimize short- and long-term adverse events all the while maintaining excellent outcomes. View Full-Text
Keywords: neuroblastoma; intermediate risk neuroblastoma; classification; treatment; low-risk neuroblastoma neuroblastoma; intermediate risk neuroblastoma; classification; treatment; low-risk neuroblastoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Meany, H.J. Non-High-Risk Neuroblastoma: Classification and Achievements in Therapy. Children 2019, 6, 5.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Children EISSN 2227-9067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top