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Children 2019, 6(1), 5; https://doi.org/10.3390/children6010005

Non-High-Risk Neuroblastoma: Classification and Achievements in Therapy

Center for Cancer and Blood Disorders, Children’s National Health System, The George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
Received: 3 December 2018 / Revised: 23 December 2018 / Accepted: 28 December 2018 / Published: 8 January 2019
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
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Abstract

Neuroblastoma, a tumor of the sympathetic nervous system, is the most common extra-cranial neoplasm of childhood. Variables with prognostic significance in patients with neuroblastoma, including age at diagnosis, disease stage, tumor histology, MYCN gene amplification, tumor cell ploidy, and the presence of segmental chromosomal aberrations are utilized to classify patients based on risk of disease recurrence. Patients with non-high-risk neuroblastoma, low- and intermediate-risk categories, represent nearly half of all newly diagnosed cases. This group has an excellent event-free and overall survival with current therapy. Over time, the objective in treatment of non-high-risk neuroblastoma has been reduction of therapy intensity to minimize short- and long-term adverse events all the while maintaining excellent outcomes. View Full-Text
Keywords: neuroblastoma; intermediate risk neuroblastoma; classification; treatment; low-risk neuroblastoma neuroblastoma; intermediate risk neuroblastoma; classification; treatment; low-risk neuroblastoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Meany, H.J. Non-High-Risk Neuroblastoma: Classification and Achievements in Therapy. Children 2019, 6, 5.

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