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Children 2018, 5(8), 107;

Late Effects and Survivorship Issues in Patients with Neuroblastoma

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA
Department of Pediatrics, Comer Children’s Hospital, University of Chicago, Chicago, IL 60637, USA
Author to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 27 July 2018 / Accepted: 1 August 2018 / Published: 6 August 2018
(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Neuroblastoma)
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Over the past two decades, marked progress has been made in understanding the biology of neuroblastoma; this has led to refined risk stratification and treatment modifications with resultant increasing 5-year survival rates for children with neuroblastoma. Survivors, however, remain at risk for a wide variety of potential treatment-related complications, or “late effects”, which may lead to excess morbidity and premature mortality in this cohort. This review summarizes the existing survivorship literature on long-term health outcomes for survivors of neuroblastoma, focusing specifically on potential injury to the endocrine, sensory, cardiovascular, pulmonary, and renal systems, as well as survivors’ treatment-related risk for subsequent neoplasms and impaired quality of life. Additional work is needed to assess the potential late effects of newer multimodality therapies with the aim of optimizing long-term medical and psychosocial outcomes for all survivors of neuroblastoma. View Full-Text
Keywords: neuroblastoma; late effects; childhood cancer; survivorship neuroblastoma; late effects; childhood cancer; survivorship

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Friedman, D.N.; Henderson, T.O. Late Effects and Survivorship Issues in Patients with Neuroblastoma. Children 2018, 5, 107.

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