Sepsis in Pediatrics: Current Concepts of Terminology and Management

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Emergency Medicine & Intensive Care Medicine".

Deadline for manuscript submissions: closed (25 November 2024) | Viewed by 1170

Special Issue Editors


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Guest Editor
1. Department of Mother and Child, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2. Emergency Clinical Hospital for Children “St. Maria”, 700309 Iasi, Romania
Interests: intensive care; epidemiology; anti-infective agents
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Medicine II, Infectious Diseases Discipline, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2. Infectious Disease Hospital "St Paraschiva", 700116 Iasi, Romania
Interests: intensive care; epidemiology; anti-infective agents

E-Mail Website
Guest Editor
1. Department of Mother and Child, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2. Emergency Clinical Hospital for Children “St. Maria”, 700309 Iasi, Romania
Interests: intensive care; epidemiology; anti-infective agents

E-Mail Website
Guest Editor
1. Pediatric Department, University of Medicine and Pharmacy Iuliu Hatieganu, 400347 Cluj-Napoca, Romania
2. Emergency Clinical Hospital for Children, 400124 Cluj Napoca, Romania
Interests: immunodeficiency and sepsis

Special Issue Information

Dear Colleagues,

Sepsis in pediatrics refers to the occurrence of sepsis, a life-threatening condition triggered by the body's extreme response to infection, in pediatric patients. Sepsis can affect infants, children, and adolescents and is a significant cause of morbidity and mortality in this population.

The Special Issue "Sepsis in Pediatrics: Current Concepts of Terminology and Management" aims to present a comprehensive overview of the latest research, clinical guidelines, and expert insights aiming toward improving the diagnosis and management of sepsis in pediatric patients. By addressing the unique challenges associated with pediatric sepsis and highlighting evidence-based strategies for optimizing care, this Special Issue aims to enhance outcomes and reduce the burden of sepsis-related morbidity and mortality in children. Furthermore, we would like to highlight the importance of a multidisciplinary approach to managing pediatric sepsis, emphasizing collaboration between pediatricians, intensivists, infectious disease specialists, nurses, and other healthcare professionals. Our goal is to discuss strategies for optimizing care delivery, including the use of protocols and guidelines, as well as the integration of technological advances to enhance the early detection and monitoring of sepsis in children.

Dr. Otilia Elena Frăsinariu
Dr. Mihaela Catalina Luca
Dr. Violeta Streangă
Dr. Bianca Simionescu
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • childhood sepsis
  • life-threatening organ dysfunction
  • septic shock
  • sepsis-induced immunosuppression
  • immunodeficiency
  • neonatal sepsis

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Published Papers (1 paper)

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Research

12 pages, 219 KiB  
Article
Assessment of Phoenix Sepsis Score, pSOFA, PELOD-2, and PRISM III in Pediatric Intensive Care
by Adriana Hadzhieva-Hristova, Darina Krumova, Temenuga Stoeva, Ralitza Georgieva and Violeta Iotova
Children 2025, 12(3), 262; https://doi.org/10.3390/children12030262 - 21 Feb 2025
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Abstract
Background/Objectives: Early identification of pediatric sepsis complications in intensive care is challenging and requires improved diagnostic tools. This study aimed to compare the Phoenix Sepsis Score (PSS), pSOFA, PELOD-2, and PRISM III in assessing clinical complexity in children with septic and critical [...] Read more.
Background/Objectives: Early identification of pediatric sepsis complications in intensive care is challenging and requires improved diagnostic tools. This study aimed to compare the Phoenix Sepsis Score (PSS), pSOFA, PELOD-2, and PRISM III in assessing clinical complexity in children with septic and critical conditions in the PICU and to identify the most suitable scale for this patient cohort. Methods: Data were collected prospectively from 53 children between June 2022 and January 2024. Patients were categorized into septic (n = 42) and non-infectious SIRS (n = 11) and further classified by outcome—with/without complications (n = 23/30). The predictive accuracy of the scoring systems was evaluated by discrimination and calibration and by recalibration for the PSS for improved performance. Results: Respiratory (18.8%) and neurological complications (9.4%) were the most common adverse events. Clinical deterioration was observed in 43.4% of cases, including one fatality. Patients with complications stayed longer in the PICU (14 ± 10 days). In the patients with complications, all scoring systems had higher median values. Only PSS showed a significant difference (p = 0.0023). PSS demonstrated the highest overall predictive accuracy (76.2%) outperforming PRISM III (62.3%) and PELOD-2 (58.5%). The pSOFA scale showed high accuracy (88.0%) in identifying patients without complications. The strongest association was between chronic disease (hazard ratio Exp(B) = 1.718) and deteriorations, while mechanical ventilation suggested a reduced risk of complications (Exp(B) = 0.509). Conclusions: PSS showed superior predictive accuracy (76.2%) for deteriorations in pediatric patients with suspected infection and proved adaptable for further validation in larger populations. Full article
(This article belongs to the Special Issue Sepsis in Pediatrics: Current Concepts of Terminology and Management)
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