Progress on Pediatric Inflammatory Multisystem Syndrome

Dear Colleagues,

Multisystem inflammatory syndrome in children (MIS-C), the potentially life-threatening condition occurring weeks after COVID-19, represents a new challenging task for pediatricians. It is characterized by fever, laboratory evidence of inflammation with multisystem (>2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic, or neurological), and markers for current or recent SARS-CoV-2 infection. MIS-C was considered Kawasaki-like because some clinical findings were reminiscent of Kawasaki's disease (KD); however, coronary arteries may not be frequently affected. It occurs in previously healthy children or adolescents, and clinical presentation is often non-specific, leading to misdiagnosis, which can even mimic surgical emergencies. The suitable treatment consists of anti-inflammatory medicaments including intravenous immunoglobulins and corticosteroids, ending up with biologic drugs.

The goal of this Special Issue in Children is to stimulate pediatricians and pediatric surgeons to share their clinical experience in diagnosis, treatment, and prognosis of MIS-C. The contributions may include basic science/translational studies, clinical trials, review articles, systematic reviews, proposals for new strategic approaches, and prospective/retrospective case studies. Please avoid single case reports.

Dr. Claudia Mandato
Guest Editor

Dr. Antonietta Giannattasio
Dr. Francesco Valitutti
Co-Guest Editors

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