Neonatal Hypoxic–Ischemic Brain Injury: Latest Advances

Dear Colleagues,

Death and disability in children worldwide have their origin predominantly in the neonatal period and mainly arise from perinatal asphyxia and preterm birth. Birth asphyxia, leading to the clinical presentation of hypoxic–ischemic encephalopathy (HIE), to a large extent affects the term-born population, but preterm infants can also be affected. Prognosis following HIE and other types of neonatal brain injury including stroke is particularly poor. Despite remarkable advances in perinatal care, the diagnosis and therapy of neonatal brain injury remain a challenge, and therapies are largely supportive. The only established clinical intervention for HIE is therapeutic hypothermia demonstrating reductions in risk of death or impairment. However, 40–50% of cooled infants still suffer from major neurological problems and, in preterm infants, therapeutic hypothermia cannot be applied due to side effects.  In recent years, established and new preclinical models have elucidated mechanisms promoting our understanding of neonatal brain injury, but unanswered questions remain. This Special Issue welcomes submissions which explore clinical and experimental advances in neonatal hypoxic–ischemic brain injury and will compile the latest results to further support clinical translation.

Prof. Dr. Mark Dzietko
Guest Editor

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