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Children
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Pediatric Gastrointestinal Diseases: Diagnosis, Management and Surgical Treatment
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Pediatric Gastrointestinal Diseases: Diagnosis, Management and Surgical Treatment

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Surgery".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 908

Special Issue Editors

Dr. Alessandro Boscarelli

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Guest Editor
Department of Pediatric Surgery and Urology, Institute of Maternal and Child Health—IRCCS "Burlo Garofolo", 34137 Trieste, Italy
Interests: pediatric surgery; gastrointestinal surgery; minimally invasive surgery; congenital abnormalities; laparoscopic surgery; abdominal surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Jurgen Schleef

E-Mail Website
Guest Editor
Department of Pediatric Surgery and Urology, Institute of Maternal and Child Health—IRCCS "Burlo Garofolo", 34137 Trieste, Italy
Interests: endoscopic surgery; prenatal diagnostics and counselling; pulmonary malformation; short bowel; bacterial translocation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The burden of gastrointestinal illness in pediatric age is high and continues to increase. Gastrointestinal diseases include a large spectrum of conditions ranging from congenital to acquired pathologies, which often require intervention. Significant progress has been made in the diagnosis and treatment of pediatric gastrointestinal diseases in recent decades. Notably, gastrointestinal endoscopy has become a key element in the diagnosis and therapy of many of these diseases that affect children. Moreover, in recent years, new technologies have been incorporated into the armamentarium of surgeons treating pediatric patients with gastrointestinal diseases. In particular, minimally invasive and robotic-assisted techniques have carved a space in cases requiring surgical correction, with evidence supporting less pain, shorter hospital stays, lower complications, and satisfying long-term outcomes. In addition, fluorescence-guided surgery has shown the advantage of allowing surgeons to better recognize anatomical structures, and artificial intelligence (AI) is currently gaining ground in the pediatric surgical field as well.

This Special Issue aims to discuss advances in the diagnosis, management, and/or surgical treatment options of gastrointestinal diseases in pediatric age. Colleagues and researchers are invited to submit their manuscripts (base science research, original studies, reviews, meta-analyses, case series, and case reports of interest).

We look forward to receiving your valuable contributions.

Dr. Alessandro Boscarelli
Dr. Jurgen Schleef
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatrics
  • gastrointestinal disorders
  • diagnosis
  • management
  • advances

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Published Papers (2 papers)

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Review

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18 pages, 1209 KiB  
Review
Current Challenges and New Strategies in Pediatric Short Bowel Syndrome: Focus on Surgical Aspects and Prevention of Complications
by Igor Sukhotnik and Haguy Kammar
Children 2025, 12(5), 621; https://doi.org/10.3390/children12050621 - 12 May 2025
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Abstract
Background: The medical management and non-transplant surgical options for children with short bowel syndrome (SBS)are maximized as first-line treatments. The purpose of this review is to summarize the currently available evidence and new management strategies in children with SBS. Methods: A systematic review [...] Read more.
Background: The medical management and non-transplant surgical options for children with short bowel syndrome (SBS)are maximized as first-line treatments. The purpose of this review is to summarize the currently available evidence and new management strategies in children with SBS. Methods: A systematic review of the literature was conducted on data from the last four years, focusing on both the effectiveness and safety of intestinal lengthening procedures, as well as frameworks for the prevention of complications and the achievement of enteral autonomy. Results: Of 546 abstracts that were screened, a total of 27 relevant full-text articles published between 2021 and 2025 were reviewed. The literature that was review showed that, over the past four years, the most commonly used lengthening procedure was serial transverse enteroplasty (STEP), which resulted in a 50–70% increase in bowel length, a decrease in PN dependency in most cases, and weaning off PN in 42–73% of patients. The longitudinal intestinal lengthening technique (LILT) has been used less frequently, allowing a similar 70% increase in small bowel length and 32–52% of patients to wean off PN, but with a higher mortality rate. The main reasons for surgery in patients with SBS patients were the inability to wean off PN, intestinal dysmotility, and bacterial overgrowth. Over the last decade, several new techniques—such as induced intestinal lengthening, distraction enterogenesis, ileal lengthening through internal distraction, and double-barrel enteroplasty—have been described as options for the treatment of a limited bowel length and less invasive modalities. Conclusions: Autologous gastrointestinal reconstructive surgery, as a part of multidisciplinary management, remains vital for managing children with SBS. Full article
(This article belongs to the Special Issue Pediatric Gastrointestinal Diseases: Diagnosis, Management and Surgical Treatment)
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9 pages, 3367 KiB  
Case Report
Pediatric Mesenteric Lipoma: Case Report and Narrative Literature Review
by Zeljko Zovko, Alessandro Boscarelli, Daniela Codrich, Rossana Bussani, Francesca Neri and Jürgen Schleef
Children 2025, 12(4), 461; https://doi.org/10.3390/children12040461 - 3 Apr 2025
Viewed by 391
Abstract
Introduction: Lipomas are among the most encountered neoplasms in clinical practice, occurring mainly in adults between the fourth and sixth decades of life. Deep-seated lipomas in children are found in the thorax, chest wall, mediastinum, pleura, pelvis, retroperitoneum, and paratesticular area. Herein, we [...] Read more.
Introduction: Lipomas are among the most encountered neoplasms in clinical practice, occurring mainly in adults between the fourth and sixth decades of life. Deep-seated lipomas in children are found in the thorax, chest wall, mediastinum, pleura, pelvis, retroperitoneum, and paratesticular area. Herein, we present a case of a three-year-old child with a giant mesenteric lipoma, along with a review of the literature on mesenteric lipomas in childhood. Case presentation: A three-year-old male toddler was referred to our hospital for severe, intermittent abdominal pain. Imaging studies at admission revealed a fat lesion occupying most of the peritoneal cavity and dislocating adjacent structures. An urgent laparotomy was performed. A giant lipoma arising from the mesentery and leading to the torsion of the mesenteric radix was confirmed and completely excised alongside an adherent small tract of jejunum. The child recovered uneventfully and is still being followed-up with no signs of recurrence. Discussion: Lipomas of the mesentery in children are very rare, and they are reported to be more common among children younger than three years of age. Mesenteric lipomas appeared to be more frequent in males than females. Even though they might be asymptomatic, voluminous lipomas can also create a lead point for intermittent torsion of the mass causing ischemia and infarction. Abdominal pain was the most frequent symptom, and the ileum was the tract of bowel more frequently involved by the tumor. Laparotomy was reported to be the preferable approach to safely remove this abdominal mass, especially in case of huge dimensions. Full article
(This article belongs to the Special Issue Pediatric Gastrointestinal Diseases: Diagnosis, Management and Surgical Treatment)
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