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Children
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Pediatric Hypoplastic Left Heart Syndrome: Diagnosis, Treatment and Management
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Pediatric Hypoplastic Left Heart Syndrome: Diagnosis, Treatment and Management

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Cardiology".

Deadline for manuscript submissions: closed (1 November 2024) | Viewed by 1430

Special Issue Editors

Dr. Lilia Oreto

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy
Interests: pediatic cardiology; congenital heart disease; pediatric cardiac surgery; ecocardiography; electrocardiography; pediatric arrhythmias
Dr. Paolo Guccione

E-Mail Website
Guest Editor
Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children Hospital, 00146 Rome, Italy
Interests: interventional management of congenital heart disease; cardiac catheterization; pediatric cardiology; pediatric cardiac surgery; ecocardiography; electrocardiography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hypoplastic left heart syndrome (HLHS) is a spectrum of complex congenital left-sided malformations sharing the common feature of an underdeveloped left ventricle, which is inadequate to support systemic circulation. Pathological entities of HLHS may include variable combinations of mitral atresia or hypoplasia, aortic atresia or hypoplasia, and a hypoplastic or interrupted aortic arch. Treatment options for HLHS are critically dependent on the degree of development of the left ventricle. While severely hypoplastic LV needs single ventricle-staged palliation, mild hypoplasia may allow for biventricular repair. Yet, there is a consistent number of borderline cases where the choice can be challenging soon after birth.

This Special Issue aims to provide a forum for contemporary research focusing on the fascinating and challenging spectrum of HLHS, particularly focusing on novel insights about diagnosis and emerging surgical options.

We welcome research focusing on all aspects of diagnosis, treatment, and management of HLHS, from neonatal age to young adults.

Dr. Lilia Oreto
Dr. Paolo Guccione
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypoplastic left heart syndrome
  • borderline left ventricle
  • single-ventricle staged palliation
  • left ventricle recruitment
  • neonatal cardiac surgery

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Published Papers (1 paper)

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Research

11 pages, 761 KiB  
Article
In-Hospital and Interstage Mortality After Late Norwood Procedure: Acknowledging the Risks When We Are Running Out of Time
by Andreea Alina Andronache, Roberta Di Cosola, Martina Evangelista, Sara Boveri, Laura Schianchi, Alessandro Giamberti and Massimo Chessa
Children 2024, 11(10), 1262; https://doi.org/10.3390/children11101262 - 18 Oct 2024
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Abstract
Background: A Norwood procedure performed after 14 days of life is notably burdened by a high mortality. We analysed the real risk and which other factors influence the mortality in late Norwood procedures. Methods: A single-centre, retrospective review of a series of consecutive [...] Read more.
Background: A Norwood procedure performed after 14 days of life is notably burdened by a high mortality. We analysed the real risk and which other factors influence the mortality in late Norwood procedures. Methods: A single-centre, retrospective review of a series of consecutive patients who underwent a surgical Norwood procedure from January 2019 until December 2023. The patients’ characteristics were considered to identify the factors associated with in-hospital and interstage mortality. Results: 35 patients were included and 71% (25) of the patients underwent the Norwood procedure after 14 days of life. The median age was 27 days (6–259 days). The in-hospital mortality was 26% (9/35) with 89% (8) of the deceased being older than 15 days at the time of the surgery. Other factors that negatively affected the outcome were a restrictive interatrial septum defect (ASD) in 66% of all patients (23), the need for mechanical ventilation in 46% (16) and systemic infection prior to surgery in 43% (15). Conclusions: Age at the time of Norwood was not associated with a higher risk of mortality, but other factors such as restrictive ASD, preoperative infection and the need for mechanical ventilation prior to surgery are even more important in predicting the short-term outcome. Full article
(This article belongs to the Special Issue Pediatric Hypoplastic Left Heart Syndrome: Diagnosis, Treatment and Management)
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