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Children
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Pediatric Urology: Current Innovations and Future Challenges for Increasingly Effective...
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Pediatric Urology: Current Innovations and Future Challenges for Increasingly Effective Care

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Nephrology & Urology".

Deadline for manuscript submissions: closed (25 April 2025) | Viewed by 1163

Special Issue Editors

Dr. Edoardo Bindi

E-Mail Website
Guest Editor
Department of Odontostomatologic and Specialized Clinical Sciences (DISCO), Marche Polytechnic University, Pediatric Surgery Unit Salesi Children’s Hospital, 60121 Ancona, AN, Italy
Interests: minimally invasive surgery; thoracic surgery; pediatric urology; robot-assisted surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giovanni Cobellis

E-Mail Website
Guest Editor
Department of Pediatric Surgery, University Politecnica of Marche, Ospedale Pediatrico G. Salesi, AOU delle Marche, Via Filippo Corridoni, 11, 60123 Ancona, AN, Italy
Interests: pediatric surgery; laparoscopic surgery; robot-assisted surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to collect scientific articles reviewing advances in pediatric urology and prospects for improving the care of pediatric patients. Pediatric urology is a rapidly evolving discipline due to the integration of new technologies, advanced surgical techniques, and multidisciplinary approaches. The included articles provide a comprehensive overview of the most significant innovations, including minimally invasive surgery techniques, the use of robotics, and laparoscopic approaches, which are revolutionizing the treatment of complex conditions such as congenital malformations and urinary tract obstructions. The editorial explores achievements to date and looks to the future, highlighting areas of expanding research. These include the development of genetics-based personalized therapies, the use of advanced biomaterials for tissue regeneration, and the potential offered by artificial intelligence in improving diagnosis and surgical planning. This Special Issue aims to provide readers with a comprehensive and up-to-date view of a branch that is rapidly redefining standards of care, aiming to improve the quality of life and long-term well-being of young patients.

Dr. Edoardo Bindi
Prof. Dr. Giovanni Cobellis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric surgery
  • urology
  • minimally invasive surgery
  • innovations
  • robot-assisted surgery

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Published Papers (1 paper)

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Research

12 pages, 1798 KiB  
Article
Urinary Microbiota of Healthy Prepubescent Girls and Boys—A Pilot Study
by Yulia L. Naboka, Mikhail I. Kogan, Johannes M. Mayr, Irina A. Gudima, Elizaveta M. Kotieva, Violetta M. Kotieva, Marina L. Chernytskaya and Vladimir V. Sizonov
Children 2025, 12(1), 40; https://doi.org/10.3390/children12010040 - 29 Dec 2024
Viewed by 733
Abstract
Background: The urinary microbiota of healthy children has rarely been studied, and potential differences between boys and girls have not been addressed. Thus, this study aimed to compare the urinary microbiota of healthy prepubescent girls and boys. Methods: We included healthy children aged [...] Read more.
Background: The urinary microbiota of healthy children has rarely been studied, and potential differences between boys and girls have not been addressed. Thus, this study aimed to compare the urinary microbiota of healthy prepubescent girls and boys. Methods: We included healthy children aged between 4 and 10 years who were free of functional or organic urinary tract diseases and had no history of urinary tract infection. We collected the mean portion of morning urine during natural micturition and determined aerobic and anaerobic microbiota using HiCrome™ chromogenic growth media. We identified microorganisms on the basis of morphotinctural properties and analyzed α- and β-diversity of microorganisms isolated from the urine of boys and girls. Results: Mean age of the children was 6.1 ± 3.2 years. In general, four-component (28.1%) as well as two-component (15.6%), three-component (15.6%), and six-component (12.5%) combinations of microorganisms prevailed in the urine of children. The urine of boys exhibited four-component combinations significantly more often than that of girls (p ˂ 0.05), while the urine of girls contained seven-component microbial combinations significantly more often than that of boys (p ˂ 0.05). Comparison of multicomponent combinations of microorganisms in boys and girls revealed an overrepresentation of Enterococcus spp. in girls (p < 0.05). Furthermore, there was a trend towards higher microbial α-diversity in the urine of girls, but the difference between girls and boys was not significant. Conclusions: The urine of healthy prepubescent children contained various aerobic–anaerobic combinations of microorganisms. Their diversity in the urine of girls and boys did not differ significantly. However, the level of α-diversity of microorganisms was higher in girls than in boys. We noted differences in the prevalence of certain taxa of microorganisms in the urine of boys and girls. Our study showed a close functional relationship between aerobic and anaerobic microorganisms detected in the urine of children in more than half of the cases. Full article
(This article belongs to the Special Issue Pediatric Urology: Current Innovations and Future Challenges for Increasingly Effective Care)
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