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Children
Special Issues
Long-Term Outcomes in Pediatric Liver Transplantation
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Long-Term Outcomes in Pediatric Liver Transplantation

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Surgery".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 1566

Special Issue Editors

Prof. Dr. Piotr Kaliciński

E-Mail Website
Guest Editor
Department of Pediatric Surgery and Organ Transplantation, The Children's Memorial Health Institute, 04-730 Warszawa, Poland
Interests: hepatobiliary surgery in children; gastrointestinal surgery in children; pediatric solid tumors; congenital malformations and neonatal surgery; abdominal organ transplantation in children (liver, kidney, intestine, multiorgan)
Special Issues, Collections and Topics in MDPI journals
Dr. Francisco Hernández Oliveros

E-Mail Website
Guest Editor
1. Department of Pediatric Surgery, Fundación Jiménez Díaz University Hospital, Madrid, Spain
2. Institute for Health Research IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain
Interests: paediatric transplantation; hepatobiliary surgery; liver transplantation; multivisceral transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Liver transplantation in children has become a routine treatment for a wide spectrum of diseases leading to acute or chronic liver failure and/or the damage of other organs and systems. 

There are multiple problems associated with liver transplantation in children: surgical, immunological, complications and co-morbidities, intensive care, infectious, ethical, psychological, and other. All of them are of great importance in achieving progress and better long-term results after liver transplantation in pediatric patients. 

We are preparing this Special Issue on “Long-Term Outcomes in Pediatric Liver Transplantation” and invite contributions from researchers and clinicians affiliated to pediatric liver transplantation centers—members of TransplantChild, a European Reference Network with the main goal of having a significant impact on children’s quality of life in the long term. One of the ways to achieve this is to promote research, innovation, and expertise in the field of transplantation. Authors from other centers are also invited to contribute to this Special Issue.

Prof. Dr. Piotr Kaliciński
Dr. Francisco Hernandez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver transplantation
  • long-term outcomes after liver transplantation
  • transplantation for hepatobiliary tumors in children
  • quality of life after liver transplantation
  • long-term problems and complications

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Published Papers (1 paper)

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Research

12 pages, 940 KiB  
Article
Challenges in Pediatric Liver Retransplantation: A Technical Perspective
by Carlotta Plessi, Roberto Tambucci, Raymond Reding, Xavier Stephenne, Isabelle Scheers, Giulia Jannone and Catherine de Magnée
Children 2024, 11(9), 1079; https://doi.org/10.3390/children11091079 - 3 Sep 2024
Viewed by 1033
Abstract
Background/Objectives: Liver retransplantation (reLT) is the only option for pediatric patients experiencing graft loss. Despite recent advancements in surgical techniques and perioperative management, it remains a high-risk procedure. Our aim is to describe our experience in pediatric reLT, focusing on the technical aspects [...] Read more.
Background/Objectives: Liver retransplantation (reLT) is the only option for pediatric patients experiencing graft loss. Despite recent advancements in surgical techniques and perioperative management, it remains a high-risk procedure. Our aim is to describe our experience in pediatric reLT, focusing on the technical aspects and surgical challenges. Methods: We systematically analyzed surgical reports from pediatric reLT performed at our center between 2006 and 2023 to identify recurrent intraoperative findings and specific surgical techniques. We focused on challenges encountered during different phases of reLT, including hepatectomy, vascular, and biliary reconstruction. Additionally, we compared patient and graft survival rates among different groups. Results: During the study period, 23 children underwent 25 reLT procedures at our center. Major surgical challenges included complex hepatectomy and vascular reconstructions, necessitating tailored approaches. Our analysis shows that patient and graft survival were significantly lower for reLT compared to primary transplantation (p = 0.002). Early reLT had a significantly lower graft survival compared to late reLT (p = 0.002), although patient survival was comparable (p = 0.278). Patient and graft survival rates were comparable between the first and second reLT (p = 0.300, p = 0.597). Patient survival tended to be higher after living-donor liver transplantation (LDLT) compared to deceased-donor liver transplantation (DDLT), although the difference was not statistically significant (p = 0.511). Conclusions: Pediatric reLT involves significant technical challenges and lower survival rates. Advances in perioperative management are crucial for improving outcomes. Further research is needed to optimize surgical strategies and evaluate the long-term benefits of LDLT in pediatric reLT. Full article
(This article belongs to the Special Issue Long-Term Outcomes in Pediatric Liver Transplantation)
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