Pediatric Inflammatory Bowel Disease: Update on Treatment and Therapeutic Endpoints

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Gastroenterology and Nutrition".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 509

Special Issue Editors


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Guest Editor
Division of Gastroenterology, Hepatology & Nutrition, Stanford Medicine Children’s Health, Palo Alto, CA, USA
Interests: pediatric inflammatory bowel disease; clinical research; quality improvement

E-Mail Website
Guest Editor
Division of Gastroenterology, Hepatology & Nutrition, Nationwide Children’s Hospital, Columbus, OH, USA
Interests: pediatric inflammatory bowel disease; clinical research; biosimilars

Special Issue Information

Dear Colleagues,

The field of inflammatory bowel disease (IBD) has moved at a rapid pace over the last few years. Areas of advancement have included new knowledge of the factors associated with the genetic predisposition, environmental triggers, and immune system dysregulation associated with IBD, along with advancement of the medical armaments for the treatment of IBD. In addition, the evidence-based development of treatment goals in the clinical care of patients has been established and includes clinical, biochemical, endoscopic and radiologic endpoints.

This Special Issue of Children will focus on pediatric IBD, providing updates on newer therapeutic agents available for achieving treatment goals and up-to-date information on monitoring strategies in clinical care, including endoscopic scoring and the use of intestinal ultrasound.

Dr. Jonathan Moses
Dr. Ross Maltz
Guest Editors

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Keywords

  • pediatrics
  • inflammatory bowel disease
  • biological products
  • drug monitoring
  • endoscopy
  • ultrasonography

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Published Papers (1 paper)

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Research

10 pages, 206 KiB  
Article
Intensified Upadacitinib Dosing for Adolescent Patients with Acute Severe Ulcerative Colitis
by Perseus V. Patel, Martina Rigmaiden, Alka Goyal, Rachel Bensen, Dorsey Bass, Jonathan Moses, Michael J. Rosen and Ruben J. Colman
Children 2025, 12(4), 401; https://doi.org/10.3390/children12040401 - 22 Mar 2025
Viewed by 361
Abstract
Background/Objectives: In adolescent patients with ulcerative colitis refractory to anti-tumor necrosis factor (TNF) therapy, episodes of acute severe ulcerative colitis (ASUC) require hospitalization or surgery. Upadacitinib can be a potential colectomy-sparing agent in adult ASUC patients receiving intensified dosing. Methods: This [...] Read more.
Background/Objectives: In adolescent patients with ulcerative colitis refractory to anti-tumor necrosis factor (TNF) therapy, episodes of acute severe ulcerative colitis (ASUC) require hospitalization or surgery. Upadacitinib can be a potential colectomy-sparing agent in adult ASUC patients receiving intensified dosing. Methods: This case series evaluates clinical outcomes of intensified rescue upadacitinib dosing in adolescent patients with ASUC. We included adolescents admitted with anti-TNF refractory ASUC treated with 30 mg twice daily upadacitinib. The primary outcome was the proportion of patients who remained colectomy-free at the most recent follow-up. Results: Five patients (aged 14–18) exhibited varying responses to upadacitinib; 2 responded rapidly, while 3 had partial response. All the patients remained on upadacitinib and were colectomy-free during follow-up (55–203 days). Three (60%) ultimately received dual advanced therapy with ustekinumab and upadacitinib. At most recent follow-up, 60% were in clinical/biochemical remission without corticosteroids. Conclusions: In select cases, intensified upadacitinib may be a potential colectomy-sparing option for adolescent ASUC patients refractory to anti-TNF therapy. Full article
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