25 Years of Proteomics in Cell Biology

Dear Colleagues,

The concept of the proteome is now 25 years old, with Marc Wilkins having coined the term at the first Siena 2D Electrophoresis Meeting in Italy in 1994. We felt that this anniversary is a good time to reflect on what proteomics has achieved in the life sciences in general and in cell biology in particular. In the last 25 years, proteomics has advanced to one of the main pillars in biomedical research and its rapid technological progress was a driving force in many scientific breakthroughs. This Special Issue of Cells will follow the milestones of the development of proteomics and its impact on cell biology during this period, and we are soliciting manuscripts on topics that have had, are having, or will have a formative influence on the field.

Using the title of the 1994 Siena Meeting “2D electrophoresis: from protein maps to genomes” as a point of departure, we would like to cover how 2D electrophoresis has developed from the initial tool for proteome mapping toward a dedicated top-down approach to resolving proteoforms, and how mass spectrometry (MS)-based techniques are currently co-evolving to address this challenging task. The rapid development of the key technology, MS, is also driving the success of bottom-up approaches, and the recent maturation of label-free protein quantification is of particular interest for this Special Issue. From the cell biological perspective, all these technical achievements have led to comprehensive inventories of the proteomes of organelles and other subcellular structures, and we plan to include articles dealing with such valuable resources for the cell biologist. Moreover, we would also like to highlight the role of proteomics as part of the integrative omics endeavor, to reach the coming era of systems biology and big data. Along similar lines, we seek to build bridges from mouse to man, and plan to illuminate how the proteomic concepts that have already fueled basic research in cell biology for many years and are now about to advance clinical applications and, eventually, the coming of age of precision medicine. We will be seeking a balance between review articles and original scientific reports in order to yield a Special Issue of broad interest for students through to experienced researchers in the field of cell biology.

Prof. Dr. Hassan Dihazi
PD Dr. Olaf Jahn
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

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