Special Issue "NF-kappa B in Inflammation and Immunity"
Deadline for manuscript submissions: 1 September 2020.
Interests: NF-κB; inflammatory disease; immune respsonse; cancer
Since nuclear factor-κB (NF-κB) was originally identified as a transcriptional factor that bound to the enhancer region of immunoglobulin κ light-chain promoter in B cells. It was thought that NF-κB plays crucial roles in B cell development; however, as research progressed, it became clear that NF-κB was involved in the expression of a wide variety of genes related to inflammation, immune responses, cell proliferation, tumorigenesis, and survival. The NF-κB family consists of five members, p65 (RelA), c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB family member is evolutionarily conserved and ubiquitously expressed in mammals. The activation of NF-κB signaling is strictly regulated. Generally, NF-κB predominantly exists in cytoplasm in an unstimulated state. In response to a variety of stimuli, NF-κB translocates into the nucleus and then binds to the promoter region of target genes. Several molecules regulating the NF-κB signaling pathway have also been identified, whereas dysregulation of the NF-κB signaling pathway, due to losing or gaining the function of the NF-κB family member and regulating molecules, leads to several diseases, such as inflammation, cancer, or metabolic disorders. This Special Issue of Cells covers much of what is known or new aspects about the NF-κB signaling pathway and its function. We believe that the reviews shown in this Issue will be of interest to a broad group of scientists who are involved in not only molecular and cell biology but also translational research.
Prof. Eijiro Jimi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Inflammatory disease
- Immune response