Regulatory Mechanisms of Skeletal Muscle Stem/Progenitor Cells in Physiological and Pathological Conditions - Series 2

Dear Colleagues,

Skeletal muscle stem/progenitor cells play essential roles in myogenesis, muscle repair, and homeostasis. In this Special Issue, we are collecting cutting-edge studies revealing the mechanisms by which the activation, proliferation, differentiation, self-renewal, and maintenance of muscle stem/progenitor cells are regulated in physiological and pathological conditions. It is especially fascinating to clarify the interaction between myogenic cells and their microenvironments. For example, non-myogenic cells, such as fibro-adipogenic precursors (FAPs) or inflammatory and immune cells, are usually indispensable for prompt muscle regeneration, but often aggravate diseases by promoting tissue damage, fibrosis, and adipocyte infiltration in pathological conditions. The factors that switch their phenotypes are still unclear. Genome-editing, direct reprogramming, and induced pluripotent stem (iPS) cells are also fascinating research fields that provide new therapeutic strategies for the cell-based treatment of muscle diseases. In this Special Issue, we hope to provide a place to exchange information, overview the field, and discuss future directions of research on muscle stem/progenitor cells.

Dr. Yuko Miyagoe-Suzuki
Guest Editor

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