Special Issue "Fibronectin in Health and Diseases"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 November 2019).
Interests: extracellular matrix; cardiovascular disease; cancer; cell biology; growth factors; enzymology; lung disease; COPD
Interests: matrix mechanotransduction; extracellular matrix; fibronectin
Interests: extracellular matrix; fibronectin; growth factors; angiogenesis; structural biology
Fibronectin is a large multimodular protein, which is incorporated in a fibrillar form in the extracellular matrix of almost every cell type. It is a major substrate for cell adhesion and migration and plays important roles in a large number of physiological processes, including wound healing and tissue regeneration, neovascularization, and embryonic development. Thus, fibronectin has been implicated in many diseases where such physiological processes are dysregulated. The ability of fibronectin to carry all these diverse functionalities depends on interactions with a large number of molecules, including adhesive and signaling cell surface receptors, other components of the extracellular matrix, and growth factors and cytokines. The regulation and integration of such a large number of interactions depends on the modular architecture and flexibility of fibronectin, which allows a large number of conformations, exposing or destroying different binding sites. Both biochemical and mechanical factors have the ability to regulate fibronectin conformation and alter fibronectin functionality.
The aim of this Special Issue is to summarize our current knowledge of the role of fibronectin in health and disease and highlight the underlying mechanisms at the cellular and molecular level. Emphasis will be given on the biochemical and mechanical forces that regulate fibronectin conformation, affect its binding partners, and lead to the activation of biochemical pathways that control cell behavior. Furthermore, an overview of the use of fibronectin in various therapeutic approaches will be given, especially the design of fibronectin-based scaffolds for tissue engineering applications. We hope that such a Special Issue will provide valuable information to the scientific community, help to identify open questions, and drive the field forward.
Prof. Matthew A Nugent
Dr. Michael L. Smith
Dr. Maria Mitsi
Manuscript Submission Information
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- conformational flexibility
- binding sites
- mechanical forces
- tissue engineering