Function of Transglutaminases in Adhesion Dynamics, Differentiation, and Cell Survival
Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 31075
Interests: transglutaminases; extracellular matrix; wound healing and fibrosis; chronic kidney disease
Interests: transglutaminases; extracellular matrix; bone remodeling; adipogenesis; osteoporosis; energy metabilism
Interests: glial cells; transglutaminases; inflammation; neurodegenerative diseases; cell adhesion and migration
Cells Special Issue on ‘Transglutaminase 2 (TG2) in Cell Adhesion Dynamics, Cell Differentiation and Cell Survival’
TG2 is a widely expressed transglutaminase whose expression and activity is associated with various human diseases, including coeliac disease, chronic lung and kidney diseases, and neurological disorders, such as multiple sclerosis. The enzyme TG2 mediates its actions via multiple activities and mechanisms, which depend on its molecular conformation, cellular redox-state, and presence of GTP and/or Ca2+. TG2 crosslinks intra- and extracellular proteins, acts as a GTPase and GTP-binding signaling protein, and mediates cell–matrix adhesion via its fibronectin-binding domain. As a consequence, TG2 has been shown to be involved in cell differentiation, migration, and survival.
Many novel compounds have been developed to modulate the conformation and activity of TG2, thereby opening avenues for therapeutic interventions. Promising initiatives are under way for coeliac disease and tissue fibrosis.
With this Special Issue, we hope to collect original research, reviews, communications or concept papers that give insights into the advances that have been made in understanding mechanisms of action of TG2 in cell adhesion, differentiation, and survival. We hope to highlight TG2 in disease processes as well as assemble current knowledge and translational prospects of TG2 research.Prof. Dr. Elisabetta Verderio Edwards
Prof. Dr. Mari T. Kaartinen
Dr. Anne-Marie van Dam
Manuscript Submission Information
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- Tissue transglutaminase
- Mechanism of action
- Cell adhesion/migration
- Cell survival
- Cell death
- TG2 inhibition
- Translational studies