Stem Cells in Tissue Engineering and Regeneration

Dear Colleagues,

Stem cells (SCs) of various origin and types have been the subject of several worldwide studies and clinical applications targeting several human diseases and tissue injuries over the last several years. Although multiple therapeutic approaches have already been proposed based on identified SC biological properties and mechanisms of action, there remains a need for: (i) a better understanding of the processes underlying the pro-reparative activity of various SC populations in various tissues; (ii) their targeted use in various tissue injuries and patients; and (iii) an enhancement of the pro-regenerative capacity of these cells prior to transplantation in vivo. Thus, several novel approaches to SC-based tissue engineering and regeneration are currently being developed in order to take stem cell biology and SC use in tissue repair to the ‘4th generation of cell-based therapies’, such as: (i) ‘cell-free’ approaches relying on the secretomic activity of SCs, including extracellular vesicle (EV) release; (ii) combining SCs with novel biocompatible scaffolds and artificial sheets to enhance their properties and form innovative tissue/organ replacements; (iii) three-dimensional (3D) ex vivo propagation and pre-treatment of SCs in conditions mimicking a specific niche of a certain tissue; (iv) genetic modifications of SCs leading to the pro-reparative properties required for repair of a certain tissue; and (v) development of GMP protocols for standardized ex vivo preparation of advanced SC-based therapies and medicinal products for use in human patients. This Topical Collection aims to present pioneering research and innovative approaches in the fields of stem cell biology, tissue engineering, and regenerative medicine.

I would like to warmly invite you to submit your unpublished original research as well as reviews that provide a comprehensive overview of a selected topic related to the fascinating subject of this Topical Collection of Cells.

Prof. Dr. Ewa Zuba-Surma
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.