Ribosome Biogenesis in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (15 September 2020) | Viewed by 1088
Special Issue Editor
Special Issue Information
Dear Colleagues,
Ribosome production is a fundamental cellular process articulated in multiple, highly coordinated steps beginning in the nucleolus and ending up in the cytoplasm. In recent years, the molecular details of this complex process have become clearer and clearer, allowing the definition of the specific role of most ribosomal components and ribosome-processing factors. In addition, we are now aware that in humans, specific alterations in ribosome biogenesis may play a major causative role in a number of severe disorders, ranging from rare inherited syndromes to acquired diseases, such as cancers of various origins. Our current understanding of ribosome biogenesis and its functional regulation is primarily based on studies performed in very different model organisms by means of different technical approaches, leading to the emergence of extremely specialized working areas within a very focused field. This Special Issue of Cells aims to contribute to the systematic organization of the recent advances in the characterization of ribosome biogenesis and also to the connection of this up-to-date knowledge to the molecular mechanisms underlying the disorders in which ribosome biogenesis is altered. Any contributions, both primary research studies and literature reviews, focused on the study of the physiological and pathological events involving ribosome biogenesis, approached in the above-presented multidisciplinary modality, are welcome.
Dr. Lorenzo Montanaro
Guest Editor
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Keywords
- Ribosome biogenesis
- Ribosomopathies
- Cancer
- Ribosomal proteins
- rRNA modifications
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