Next Article in Journal
Nutritional Stress in Head and Neck Cancer Originating Cell Lines: The Sensitivity of the NRF2-NQO1 Axis
Next Article in Special Issue
How to Avoid a No-Deal ER Exit
Previous Article in Journal
Hyperglycemia-Induced Aberrant Cell Proliferation; A Metabolic Challenge Mediated by Protein O-GlcNAc Modification
Previous Article in Special Issue
Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery

Membrane-Bound Meet Membraneless in Health and Disease

Hubrecht Institute of the Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands
Department of Biomedical Science of Cells and Systems, University Medical Center Groningen, 9713 AV Groningen, The Netherlands
Author to whom correspondence should be addressed.
Cells 2019, 8(9), 1000;
Received: 31 July 2019 / Revised: 26 August 2019 / Accepted: 27 August 2019 / Published: 29 August 2019
(This article belongs to the Special Issue Membrane Traffic in Health and Disease)
Membraneless organelles (MLOs) are defined as cellular structures that are not sealed by a lipidic membrane and are shown to form by phase separation. They exist in both the nucleus and the cytoplasm that is also heavily populated by numerous membrane-bound organelles. Even though the name membraneless suggests that MLOs are free of membrane, both membrane and factors regulating membrane trafficking steps are emerging as important components of MLO formation and function. As a result, we name them biocondensates. In this review, we examine the relationships between biocondensates and membrane. First, inhibition of membrane trafficking in the early secretory pathway leads to the formation of biocondensates (P-bodies and Sec bodies). In the same vein, stress granules have a complex relationship with the cyto-nuclear transport machinery. Second, membrane contributes to the regulated formation of phase separation in the cells and we will present examples including clustering at the plasma membrane and at the synapse. Finally, the whole cell appears to transit from an interphase phase-separated state to a mitotic diffuse state in a DYRK3 dependent manner. This firmly establishes a crosstalk between the two types of cell organization that will need to be further explored. View Full-Text
Keywords: membrane; organelles; phase separation membrane; organelles; phase separation
Show Figures

Figure 1

MDPI and ACS Style

Zhang, C.; Rabouille, C. Membrane-Bound Meet Membraneless in Health and Disease. Cells 2019, 8, 1000.

AMA Style

Zhang C, Rabouille C. Membrane-Bound Meet Membraneless in Health and Disease. Cells. 2019; 8(9):1000.

Chicago/Turabian Style

Zhang, Chujun, and Catherine Rabouille. 2019. "Membrane-Bound Meet Membraneless in Health and Disease" Cells 8, no. 9: 1000.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop