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Open AccessReview

Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases

Institute of Cell Biology and Immunology and Stuttgart Research Center Systems Biology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1478;
Received: 18 October 2019 / Revised: 15 November 2019 / Accepted: 18 November 2019 / Published: 21 November 2019
(This article belongs to the Special Issue Membrane Traffic in Health and Disease)
As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases coordinate a wide range of biological processes such as cell adhesion, motility, and polarity. In the last years, Rho GTPases have also been recognized to control intracellular membrane sorting and trafficking steps directly; however, how Rho GTPase signaling is regulated at endomembranes is still poorly understood. In this review, we will specifically address the local Rho GTPase pools coordinating intracellular membrane trafficking with a focus on the endo- and exocytic pathways. We will further highlight the spatiotemporal molecular regulation of Rho signaling at endomembrane sites through Rho regulatory proteins, the GEFs and GAPs. Finally, we will discuss the contribution of dysregulated Rho signaling emanating from endomembranes to the development and progression of cancer.
Keywords: Rho GTPases; secretory pathway; endocytosis; cancer Rho GTPases; secretory pathway; endocytosis; cancer
MDPI and ACS Style

Olayioye, M.A.; Noll, B.; Hausser, A. Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases. Cells 2019, 8, 1478.

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