Special Issue "Drosophila: A Model for Genetic Research"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".

Deadline for manuscript submissions: closed (31 July 2021).

Special Issue Editor

Dr. Krzysztof Jagla
E-Mail Website
Guest Editor
Institute of Genetics Reproduction and Development, iGReD, INSERM U1103, CNRS UMR6293, University of Clermont Auvergne, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France
Interests: developmental genetics and systems biology, with Drosophila as a model system, applied to study gene regulatory networks controlling diversification of muscle and heart cell types in normal and in pathological conditions

Special Issue Information

Dear Colleagues,

Drosophila, with powerfull genetic tools,  has a long history as a model organism, and is currently integral to both fundamental and applied biological research. The goal of this Special Issue is to provide examples of how the Drosophila model is applied nowadays in order to progress our understanding of pathogenic mechanisms and normal developmental processes; to show how large and diverse Drosophila model applications are and how much we can learn from. This includes, but is not restricted to, understanding the genome regulation and functions, roles of conserved transcriptional regulators, stem cell biology, and modeling of the disease and aging. I am convinced that with your prominent contributions, this Special Issue will be of interest to a large audience and, at the same time, will be a reference for the Drosophila community.

Dr. Krzysztof Jagla
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Drosophila
  • developmental genetics
  • transcriptional regulation
  • genomics
  • stem cell
  • disease modeling
  • aging
  • clock genes

Published Papers (6 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

Article
The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes
Cells 2021, 10(5), 1144; https://doi.org/10.3390/cells10051144 - 10 May 2021
Viewed by 534
Abstract
Drosophila melanogaster sbr (small bristles) is an orthologue of the Nxf1 (nuclear export factor 1) genes in different Opisthokonta. The known function of Nxf1 genes is the export of various mRNAs from the nucleus to the cytoplasm. The cytoplasmic [...] Read more.
Drosophila melanogaster sbr (small bristles) is an orthologue of the Nxf1 (nuclear export factor 1) genes in different Opisthokonta. The known function of Nxf1 genes is the export of various mRNAs from the nucleus to the cytoplasm. The cytoplasmic localization of the SBR protein indicates that the nuclear export function is not the only function of this gene in Drosophila. RNA-binding protein SBR enriches the nucleus and cytoplasm of specific neurons and glial cells. In sbr12 mutant males, the disturbance of medulla boundaries correlates with the defects of photoreceptor axons pathfinding, axon bundle individualization, and developmental neurodegeneration. RNA-binding protein SBR participates in processes allowing axons to reach and identify their targets. Full article
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Show Figures

Graphical abstract

Review

Jump to: Research

Review
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
Cells 2021, 10(9), 2387; https://doi.org/10.3390/cells10092387 - 10 Sep 2021
Viewed by 430
Abstract
Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the [...] Read more.
Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the development of more efficient therapies and improve patient care. To do so, multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the Drosophila accessory gland. With a high level of conservation of major signaling pathways implicated in human disease, this functional equivalent of the prostate represents a powerful, inexpensive, and rapid in vivo model to study epithelial carcinogenesis. The purpose of this review is to quickly overview the existing prostate cancer models, including their strengths and limitations. In particular, we discuss how the Drosophila accessory gland can be integrated as a convenient complementary model by bringing new understanding in the mechanisms driving prostate epithelial tumorigenesis, from initiation to metastatic formation. Full article
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Review
Impact of Microorganisms and Parasites on Neuronally Controlled Drosophila Behaviours
Cells 2021, 10(9), 2350; https://doi.org/10.3390/cells10092350 - 08 Sep 2021
Viewed by 278
Abstract
Like all invertebrates, flies such as Drosophila lack an adaptive immune system and depend on their innate immune system to protect them against pathogenic microorganisms and parasites. In recent years, it appears that the nervous systems of eucaryotes not only control animal behavior [...] Read more.
Like all invertebrates, flies such as Drosophila lack an adaptive immune system and depend on their innate immune system to protect them against pathogenic microorganisms and parasites. In recent years, it appears that the nervous systems of eucaryotes not only control animal behavior but also cooperate and synergize very strongly with the animals’ immune systems to detect and fight potential pathogenic threats, and allow them to adapt their behavior to the presence of microorganisms and parasites that coexist with them. This review puts into perspective the latest progress made using the Drosophila model system, in this field of research, which remains in its infancy. Full article
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Show Figures

Figure 1

Review
Ion Channels in Epithelial Dynamics and Morphogenesis
Cells 2021, 10(9), 2280; https://doi.org/10.3390/cells10092280 - 01 Sep 2021
Viewed by 403
Abstract
Mechanosensitive ion channels mediate the neuronal sensation of mechanical signals such as sound, touch, and pain. Recent studies point to a function of these channel proteins in cell types and tissues in addition to the nervous system, such as epithelia, where they have [...] Read more.
Mechanosensitive ion channels mediate the neuronal sensation of mechanical signals such as sound, touch, and pain. Recent studies point to a function of these channel proteins in cell types and tissues in addition to the nervous system, such as epithelia, where they have been little studied, and their role has remained elusive. Dynamic epithelia are intrinsically exposed to mechanical forces. A response to pull and push is assumed to constitute an essential part of morphogenetic movements of epithelial tissues, for example. Mechano-gated channels may participate in sensing and responding to such forces. In this review, focusing on Drosophila, we highlight recent results that will guide further investigations concerned with the mechanistic role of these ion channels in epithelial cells. Full article
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Show Figures

Figure 1

Review
Drosophila, an Integrative Model to Study the Features of Muscle Stem Cells in Development and Regeneration
Cells 2021, 10(8), 2112; https://doi.org/10.3390/cells10082112 - 17 Aug 2021
Viewed by 418
Abstract
Muscle stem cells (MuSCs) are essential for muscle growth, maintenance and repair. Over the past decade, experiments in Drosophila have been instrumental in understanding the molecular and cellular mechanisms regulating MuSCs (also known as adult muscle precursors, AMPs) during development. A large number [...] Read more.
Muscle stem cells (MuSCs) are essential for muscle growth, maintenance and repair. Over the past decade, experiments in Drosophila have been instrumental in understanding the molecular and cellular mechanisms regulating MuSCs (also known as adult muscle precursors, AMPs) during development. A large number of genetic tools available in fruit flies provides an ideal framework to address new questions which could not be addressed with other model organisms. This review reports the main findings revealed by the study of Drosophila AMPs, with a specific focus on how AMPs are specified and properly positioned, how they acquire their identity and which are the environmental cues controlling their behavior and fate. The review also describes the recent identification of the Drosophila adult MuSCs that have similar characteristics to vertebrates MuSCs. Integration of the different levels of MuSCs analysis in flies is likely to provide new fundamental knowledge in muscle stem cell biology largely applicable to other systems. Full article
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Show Figures

Figure 1

Review
Drosophila Models Rediscovered with Super-Resolution Microscopy
Cells 2021, 10(8), 1924; https://doi.org/10.3390/cells10081924 - 29 Jul 2021
Viewed by 448
Abstract
With the advent of super-resolution microscopy, we gained a powerful toolbox to bridge the gap between the cellular- and molecular-level analysis of living organisms. Although nanoscopy is broadly applicable, classical model organisms, such as fruit flies, worms and mice, remained the leading subjects [...] Read more.
With the advent of super-resolution microscopy, we gained a powerful toolbox to bridge the gap between the cellular- and molecular-level analysis of living organisms. Although nanoscopy is broadly applicable, classical model organisms, such as fruit flies, worms and mice, remained the leading subjects because combining the strength of sophisticated genetics, biochemistry and electrophysiology with the unparalleled resolution provided by super-resolution imaging appears as one of the most efficient approaches to understanding the basic cell biological questions and the molecular complexity of life. Here, we summarize the major nanoscopic techniques and illustrate how these approaches were used in Drosophila model systems to revisit a series of well-known cell biological phenomena. These investigations clearly demonstrate that instead of simply achieving an improvement in image quality, nanoscopy goes far beyond with its immense potential to discover novel structural and mechanistic aspects. With the examples of synaptic active zones, centrosomes and sarcomeres, we will explain the instrumental role of super-resolution imaging pioneered in Drosophila in understanding fundamental subcellular constituents. Full article
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Show Figures

Figure 1

Back to TopTop