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Article

The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes

1
Department of Genetics and Biotechnology, Saint-Petersburg State University, Universitetskaya Emb. 7/9, 199034 St. Petersburg, Russia
2
A. Tsyb Medical Radiological Research Center—Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva Str. 4, 249036 Obninsk, Russia
3
Institute of Gene Biology, Russian Academy of Sciences, Vavilov St. 34/5, 119334 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Krzysztof Jagla
Cells 2021, 10(5), 1144; https://doi.org/10.3390/cells10051144
Received: 18 April 2021 / Revised: 5 May 2021 / Accepted: 6 May 2021 / Published: 10 May 2021
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
Drosophila melanogaster sbr (small bristles) is an orthologue of the Nxf1 (nuclear export factor 1) genes in different Opisthokonta. The known function of Nxf1 genes is the export of various mRNAs from the nucleus to the cytoplasm. The cytoplasmic localization of the SBR protein indicates that the nuclear export function is not the only function of this gene in Drosophila. RNA-binding protein SBR enriches the nucleus and cytoplasm of specific neurons and glial cells. In sbr12 mutant males, the disturbance of medulla boundaries correlates with the defects of photoreceptor axons pathfinding, axon bundle individualization, and developmental neurodegeneration. RNA-binding protein SBR participates in processes allowing axons to reach and identify their targets. View Full-Text
Keywords: neurogenesis; optic lobe; Drosophila; NXF; RNA-binding protein neurogenesis; optic lobe; Drosophila; NXF; RNA-binding protein
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MDPI and ACS Style

Mamon, L.; Yakimova, A.; Kopytova, D.; Golubkova, E. The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes. Cells 2021, 10, 1144. https://doi.org/10.3390/cells10051144

AMA Style

Mamon L, Yakimova A, Kopytova D, Golubkova E. The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes. Cells. 2021; 10(5):1144. https://doi.org/10.3390/cells10051144

Chicago/Turabian Style

Mamon, Ludmila, Anna Yakimova, Daria Kopytova, and Elena Golubkova. 2021. "The RNA-Binding Protein SBR (Dm NXF1) Is Required for the Constitution of Medulla Boundaries in Drosophila melanogaster Optic Lobes" Cells 10, no. 5: 1144. https://doi.org/10.3390/cells10051144

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