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Drosophila Models Rediscovered with Super-Resolution Microscopy

Institute of Genetics, Biological Research Centre, Temesvári krt. 62, H-6726 Szeged, Hungary
Doctoral School of Multidisciplinary Medical Science, Faculty of Medicine, University of Szeged, H-6725 Szeged, Hungary
Foundation for the Future of Biomedical Sciences in Szeged, Szeged Scientists Academy, Pálfy u. 52/d, H-6725 Szeged, Hungary
Department of Genetics, University of Szeged, H-6726 Szeged, Hungary
Authors to whom correspondence should be addressed.
Academic Editor: Krzysztof Jagla
Cells 2021, 10(8), 1924;
Received: 2 July 2021 / Revised: 22 July 2021 / Accepted: 27 July 2021 / Published: 29 July 2021
(This article belongs to the Special Issue Drosophila: A Model for Genetic Research)
With the advent of super-resolution microscopy, we gained a powerful toolbox to bridge the gap between the cellular- and molecular-level analysis of living organisms. Although nanoscopy is broadly applicable, classical model organisms, such as fruit flies, worms and mice, remained the leading subjects because combining the strength of sophisticated genetics, biochemistry and electrophysiology with the unparalleled resolution provided by super-resolution imaging appears as one of the most efficient approaches to understanding the basic cell biological questions and the molecular complexity of life. Here, we summarize the major nanoscopic techniques and illustrate how these approaches were used in Drosophila model systems to revisit a series of well-known cell biological phenomena. These investigations clearly demonstrate that instead of simply achieving an improvement in image quality, nanoscopy goes far beyond with its immense potential to discover novel structural and mechanistic aspects. With the examples of synaptic active zones, centrosomes and sarcomeres, we will explain the instrumental role of super-resolution imaging pioneered in Drosophila in understanding fundamental subcellular constituents. View Full-Text
Keywords: nanoscopy; super-resolution microscopy; SIM; STED; SMLM; Drosophila; active zone; centrosome; sarcomere nanoscopy; super-resolution microscopy; SIM; STED; SMLM; Drosophila; active zone; centrosome; sarcomere
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MDPI and ACS Style

Szikora, S.; Görög, P.; Kozma, C.; Mihály, J. Drosophila Models Rediscovered with Super-Resolution Microscopy. Cells 2021, 10, 1924.

AMA Style

Szikora S, Görög P, Kozma C, Mihály J. Drosophila Models Rediscovered with Super-Resolution Microscopy. Cells. 2021; 10(8):1924.

Chicago/Turabian Style

Szikora, Szilárd, Péter Görög, Csaba Kozma, and József Mihály. 2021. "Drosophila Models Rediscovered with Super-Resolution Microscopy" Cells 10, no. 8: 1924.

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