Understanding the Impact of Dopamine Receptors Diversity in the Central Nervous System

Dear Colleagues,

The neurotransmitter dopamine interacts with five types of dopamine receptors (D₁R–D₅R) to regulate a great variety of functions in the brain, including learning, motivation, and movement. These dopamine receptors belong to the superfamily of G protein-coupled receptors and have been classified in two families (D1-like and D2-like) according to their pharmacological and biochemical properties. Dysfunction of dopamine neurotransmission and its receptors leads to several neurological disorders such as Parkinson’s and Huntington’s diseases, addiction, and attention deficit/hyperactivity disorder. Since the cloning of the dopamine receptors in the 1990s, numerous studies have been conducted to elucidate the specific function of each of them. In addition, research on dopamine receptors has also focused on their ability to form homo- and heteroreceptor complexes, which significantly increase the variety and complexity of the integrative mechanisms of dopamine signal.

The aim of this Topical Collection is to compile research and review articles studying the molecular biology, pharmacology, and function of dopamine receptors, especially those less studied, i.e., D₃R, D₄R, and D₅R. Articles on other important aspects of dopamine homo- and heteroreceptor complexes relevant to both health and neurological disorders are also welcome.

Dr. Alicia Rivera
Dr. Belén Gago
Collection Editors

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