New Pathogenic Mechanisms in Autoimmune Diseases: Focus on Immune-Regulatory Pathways
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2611
Special Issue Editors
Interests: systemic lupus erythematosus; rheumatoid arthritis; Sjogren syndrome; antiphospholipid syndrome; arthritis induced by immune checkpoint inhibitors
Special Issues, Collections and Topics in MDPI journals
Interests: autoimmune diseases; systemic lupus erythematosus; genetic factors; pathogenic mechanisms; biomarkers
Interests: autoimmune diseases; systemic lupus erythematosus; genetic factors; pathogenic mechanisms; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is with great pleasure and enthusiasm that we present this Special Issue of Cells, entitled “New Pathogenic Mechanisms in Autoimmune Diseases: Focus on Immune-Regulatory Pathways”.
This issue will investigate the recent pathogenic aspects underlining autoimmune diseases in order to unveil the complexity of these conditions, especially systemic lupus erythematosus.
The spread of drugs that target immune checkpoints in cancer treatment has refocused immunology regarding the possible role of co-stimulatory molecules in the pathogenesis of autoimmune diseases.
In this field, some pathways have been clearly defined, leading to the development of Abatacept (CTLA4–Ig), a fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Indeed, several studies demonstrated the efficacy and safety of this biological drug in rheumatoid arthritis.
Furthermore, other promising mechanisms have been investigated, including other co-stimulatory molecules and immune-regulatory cells.
This Special Issue aims to present new, exploratory research concerning immune-regulatory pathways in systemic autoimmune diseases, considering the following conditions:
- Systemic Lupus Erythematosus;
- Inflammatory arthropathies;
- Sjögren Syndrome;
- Systemic Sclerosis;
- Myositis and Vasculitis;
- Immune-related adverse events associated with treatment with immune-checkpoints inhibitors.
We look forward to receiving your contributions summarizing or explaining your research for this Special Issue.
Dr. Fulvia Ceccarelli
Dr. Francesco Natalucci
Dr. Giulio Olivieri
Guest Editors
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Keywords
- autoimmune diseases
- pathogenesis
- cells
- immune regulatory mechanisms
- co-stimulatory molecules
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