Novel Signaling Mechanisms of G Protein-Coupled Receptors
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 May 2025 | Viewed by 252
Special Issue Editor
Interests: physiology; signal transduction; G-protein-coupled receptors (GPCRs); angiotensin II; renin-angiotensin system (RAS)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Members of the G protein-coupled receptor (GPCR) superfamily represent the largest group of cell membrane receptors, responsible for transducing a vast array of signals that lead to diverse cellular responses. Their dysfunction is implicated in numerous diseases, including cancer, making GPCRs one of the primary targets for the current marketed drugs. GPCRs are also one of the most studied proteins in molecular pharmacology.
GPCRs exhibit multiple conformations and signaling possibilities. Biased ligands can induce selective signaling of the receptors, adding another layer of complexity to GPCR functions. Activated GPCRs are able to initiate waves of signaling events through various mechanisms, including activation of G proteins, binding to β-arrestins and transactivation of other receptors, and even some internalized receptors can induce signaling.
The aim of this Special Issue is to provide an overview of the latest findings in the novel aspects of GPCR functions and signaling. Therefore, this Special Issue of Cells invites contributions of review articles and original research papers that cover the novel, exciting aspects of GPCRs, providing a better understanding of the complexity of their functions.
Dr. András Balla
Guest Editor
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Keywords
- G protein-coupled receptor (GPCR)
- signal transduction
- biased agonism
- functional selectivity
- arrestin
- receptor cross-talk
- receptor dimerization
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