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Geriatrics
Special Issues
Aging and Age-Related Diseases: Biomarkers, Epidemiological and Clinical Studies
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Aging and Age-Related Diseases: Biomarkers, Epidemiological and Clinical Studies

A special issue of Geriatrics (ISSN 2308-3417).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 3126

Special Issue Editors

Dr. Gérard Lizard

E-Mail Website
Guest Editor
Team "Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism", Université de Bourgogne Franche-Comté, 21000 Dijon, France
Interests: lipids; oxysterols; fatty acids; polyphenols; oils; oxidation; inflammation; mitochondria; peroxisomes; lysosomes; apoptosis; autophagy; natural products; synthethic molecules; biomarkers; neurodegeneration; neurodegenerative diseases; aging; age-related diseases; nanoparticles; targeted therapy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Pierre Jouanny

E-Mail Website
Guest Editor
Team U1093 CAPS “Cognition, Action and Sensorimotor Plasticity”, Université de Bourgogne, 21000 Dijon, France
Interests: Alzheimer’s disease; frailty; ageing process; epidemiology; successful aging
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sonia Hammami

E-Mail Website
Guest Editor
Lab-NAFS ‘Nutritio—Functional Food & Vascular Health’, Faculty of Medicine, LR12ES05, University Monastir, Monastir 5000, Tunisia
Interests: aging; geriatrics; frailty; sarcopenia; Alzheimer’s disease; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During the last decades, the percentage of people over 65, as well as the average lifespan, has increased considerably and is expected to increase further in the coming years. Aging in good health has therefore become a societal and economic issue. Therefore, understanding the mechanisms of aging and preventing it by opposing the onset of age-related diseases is a public health issue. In this context, it is important to identify the genetic and epigenetic factors that can influence aging and to determine the associated mechanisms. It is now crucial to determine strategies to slow aging in order to oppose the onset of age-related diseases. Identifying predictive biomarkers of age-related diseases is a major challenge, as well as the discovery of molecules that can oppose aging and the occurrence of associated diseases. This Special Issue of Geriatrics entitled “Aging and Age-Related Diseases: Biomarkers, Epidemiological and Clinical Studies” aims to bring together relevant research works dealing with cellular and molecular, pharmacological, nutritional, epidemiological, and clinical aspects of aging and age-related diseases.

Dr. Gérard Lizard
Prof. Dr. Pierre Jouanny
Prof. Dr. Sonia Hammami
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Geriatrics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • age-related diseases
  • pathophysiology
  • cell mechanisms
  • therapies
  • biomarkers

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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17 pages, 3158 KiB  
Article
Particularities of Cataract Surgery in Elderly Patients: Corneal Structure and Endothelial Morphological Changes after Phacoemulsification
by Adela Laura Ciorba, Alin Teusdea, George Roiu and Daniela Simona Cavalu
Geriatrics 2024, 9(3), 77; https://doi.org/10.3390/geriatrics9030077 - 8 Jun 2024
Viewed by 868
Abstract
The aim of this study was to evaluate the influence of ultrasounds used in phacoemulsification during cataract surgery on the corneal structure and morphology in patients over 65 years. We compared the outcomes of phacoemulsification techniques in terms of corneal cell morphology in [...] Read more.
The aim of this study was to evaluate the influence of ultrasounds used in phacoemulsification during cataract surgery on the corneal structure and morphology in patients over 65 years. We compared the outcomes of phacoemulsification techniques in terms of corneal cell morphology in 77 patients over 65 years old and 43 patients under 65 years old. Corneal cell density, central corneal thickness and hexagonality were measured preoperatively and post-surgery (at 1 and 4 weeks) by specular microscopy. The effect of gender, axial length and anterior chamber depth on the parameters of corneal endothelium were evaluated. In both groups, a progressive decrease in endothelial cells was observed, starting from the first week post-surgery until the fourth postoperative week. The central corneal thickness increased in both groups with maximum values at the first week postoperatively, while their initial values were restored in the fourth week post-surgery, with no statistical difference between groups. Statistically significant differences were noticed in terms of cell hexagonality in the group over 65, showing smaller hexagonality at all preoperative and postoperative time points compared to group under 65. Our result highlights the importance of routine specular microscopy performed before surgery, regardless the age of the patients, with caution and careful attention to the phaco power intensity, ultrasound energy consumption and intraoperative manipulation of instruments, as well as proper use of viscoelastic substances to reduce corneal endothelium damage, especially in elderly patients. Full article
(This article belongs to the Special Issue Aging and Age-Related Diseases: Biomarkers, Epidemiological and Clinical Studies)
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Review

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11 pages, 547 KiB  
Review
Statistical Considerations for the Design and Analysis of Pragmatic Trials in Aging Research
by Ashuin Kammar-García, Liliana Aline Fernández-Urrutia, Jorge Alberto Guevara-Díaz and Javier Mancilla-Galindo
Geriatrics 2024, 9(3), 75; https://doi.org/10.3390/geriatrics9030075 - 4 Jun 2024
Viewed by 877
Abstract
Pragmatic trials aim to assess intervention efficacy in usual patient care settings, contrasting with explanatory trials conducted under controlled conditions. In aging research, pragmatic trials are important designs for obtaining real-world evidence in elderly populations, which are often underrepresented in trials. In this [...] Read more.
Pragmatic trials aim to assess intervention efficacy in usual patient care settings, contrasting with explanatory trials conducted under controlled conditions. In aging research, pragmatic trials are important designs for obtaining real-world evidence in elderly populations, which are often underrepresented in trials. In this review, we discuss statistical considerations from a frequentist approach for the design and analysis of pragmatic trials. When choosing the dependent variable, it is essential to use an outcome that is highly relevant to usual medical care while also providing sufficient statistical power. Besides traditionally used binary outcomes, ordinal outcomes can provide pragmatic answers with gains in statistical power. Cluster randomization requires careful consideration of sample size calculation and analysis methods, especially regarding missing data and outcome variables. Mixed effects models and generalized estimating equations (GEEs) are recommended for analysis to account for center effects, with tools available for sample size estimation. Multi-arm studies pose challenges in sample size calculation, requiring adjustment for design effects and consideration of multiple comparison correction methods. Secondary analyses are common but require caution due to the risk of reduced statistical power and false-discovery rates. Safety data collection methods should balance pragmatism and data quality. Overall, understanding statistical considerations is crucial for designing rigorous pragmatic trials that evaluate interventions in elderly populations under real-world conditions. In conclusion, this review focuses on various statistical topics of interest to those designing a pragmatic clinical trial, with consideration of aspects of relevance in the aging research field. Full article
(This article belongs to the Special Issue Aging and Age-Related Diseases: Biomarkers, Epidemiological and Clinical Studies)
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