Molecular Mechanisms and Physiology Associated with the Blood–Brain Barrier
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 13994
Special Issue Editor
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet; peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
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Dear Colleagues,
The blood–brain barrier (BBB) is a physical and metabolic barrier that isolates the brain from the rest of the body. It intervenes daily in the regulation of cerebral homeostasis. It was long considered that only small lipophilic molecules could passively diffuse through these successive layers of phospholipids to reach the brain tissue and influence neurotransmission or the reproduction of microorganisms, viruses, or tumor cells there. Different strategies have been implemented to reduce the size of molecules, make them more lipophilic, or to even deliver substances directly to the brain intrathecally. Some highly hydrophilic molecules can pass the BBB, while some lipophilic anticancer drugs do not cross; some molecules with identical physicochemical properties cannot pass the BBB so easily. There are transporters at the endothelial cell level, allowing the brain to cover its metabolic needs by taking up different elementary nutrients such as glucose or amino acids. In pharmacology, these transporters allow the passage of drugs such as levodopa. The study of these facilitated transport mechanisms opens interesting perspectives for the development of new drugs targeting the nervous system, which could take advantage of these access routes to cross the blood–brain barrier despite their hydrophilic character. These transporters could be the site of drug interactions or genetic polymorphisms. Geneticists are beginning to describe such polymorphisms, which could explain individual variations in response to certain drugs. There are also effective efflux pumps explaining drug resistance (e.g., p-glycoprotein). Selective endocytosis is also present, allowing the cerebral penetration of certain large molecules such as insulin, transferrin, or lipoproteins. Finally, there is cerebrospinal fluid which eliminates the molecules that have crossed the BBB. The BBB is also not uniform over the entire surface of the brain; in certain places it is looser (hypothalamus), which allows a passive and non-selective diffusion of molecules towards the cerebral parenchyma.
Gathering a better understanding of the cellular and molecular mechanisms involved in the processes of the passage of molecules/drugs/nutrients to the brain is essential. Many areas are thus targeted in this Special Issue, such as blood–brain barrier and neurodegenerative diseases, blood–brain barrier and cancer, and blood–brain barrier and diet.
Dr. Anne Vejux
Guest Editor
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Keywords
- blood–brain barrier
- neurodegenerative diseases
- cancer
- diet
- pharmacology
- transporters
- receptors
- microglial cells
- tanycytes
- fenestrated vessels
- hypothalamus
- plasticity
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