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Mediterranean Nutrients and Oils
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Mediterranean Nutrients and Oils

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 34528

Special Issue Editors

Dr. Adil El Midaoui

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Guest Editor
1. Department of Pharmacology and Physiology, Faculty of Medicine, University de Montréal, Montreal, QC H3T 1A8, Canada
2. Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes 50050, Morocco
Interests: type 2 diabetes; hypertension; obesity; oxidative stress; anti-oxidants; argan oil
Special Issues, Collections and Topics in MDPI journals
Dr. Gérard Lizard

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Guest Editor
Team "Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism", Université de Bourgogne, 21000 Dijon, France
Interests: lipids; oxysterols; fatty acids; polyphenols; oils; oxidation; inflammation; mitochondria; peroxisomes; lysosomes; apoptosis; autophagy; natural products; synthethic molecules; biomarkers; neurodegeneration; neurodegenerative diseases; aging; age-related diseases; nanoparticles; targeted therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Mediterranean diet is characterized by high intake levels of fruit, vegetables, olive oil, whole grains, legumes, and blue fish, with restrictions on red meat and dairy intake, moderate but regular consumption of red wine, and low consumption of manufactured foods including sugar-sweetened foods and drinks. It is considered one of the healthiest diets for health and longevity.

Much evidence suggests that the Mediterranean-style diet provides several dietary compounds that have been reported to exert beneficial biological effects against a wide spectrum of chronic illnesses and age-related diseases, such as cardiovascular, neurodegenerative, mental, eye, inflammatory, and infectious diseases. Among the bioactive nutrients identified as protective factors, natural polyphenols, carotenoids, retinoids, and polyunsaturated fatty acids have been reported to possess antioxidant, anti-inflammatory, immune-modulatory, and anti-tumoral properties.

Although huge advances have been made in recent years in epidemiological research into the beneficial effects of the Mediterranean diet, especially in the prevention of cardiovascular diseases, there is still insufficient scientific evidence on the molecular mechanisms by which its nutrients and compounds exert their beneficial effects on human health.

This Special Issue of Nutrients, entitled Mediterranean Nutrients and Oils, aims to provide the latest evidence regarding the impact of the Mediterranean diet and its nutrients and oils on human wellbeing and health. We hope to receive articles from outstanding experts on this topic. Both original epidemiological studies on humans and original articles on cell and animal models, as well as review articles providing insight into the physiology and molecular benefits of the Mediterranean diet and its bioactives, are welcome.

Dr. Adil El Midaoui
Dr. Gérard Lizard
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mediterranean diet
  • dietary and essential oils
  • natural products
  • functional food

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Related Special Issue

Published Papers (3 papers)

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Research

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17 pages, 2593 KiB  
Article
Agarwood Oil Nanoemulsion Attenuates Cigarette Smoke-Induced Inflammation and Oxidative Stress Markers in BCi-NS1.1 Airway Epithelial Cells
by Gabriele De Rubis, Keshav Raj Paudel, Bikash Manandhar, Sachin Kumar Singh, Gaurav Gupta, Raniya Malik, Jessie Shen, Aniss Chami, Ronan MacLoughlin, Dinesh Kumar Chellappan, Brian Gregory George Oliver, Philip Michael Hansbro and Kamal Dua
Nutrients 2023, 15(4), 1019; https://doi.org/10.3390/nu15041019 - 17 Feb 2023
Cited by 27 | Viewed by 4548
Abstract
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as cough and wheezing that lead to irreversible airway damage and hyperresponsiveness. The primary risk factor for COPD is chronic cigarette smoke exposure, which promotes [...] Read more.
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as cough and wheezing that lead to irreversible airway damage and hyperresponsiveness. The primary risk factor for COPD is chronic cigarette smoke exposure, which promotes oxidative stress and a general pro-inflammatory condition by stimulating pro-oxidant and pro-inflammatory pathways and, simultaneously, inactivating anti-inflammatory and antioxidant detoxification pathways. These events cause progressive damage resulting in impaired cell function and disease progression. Treatments available for COPD are generally aimed at reducing the symptoms of exacerbation. Failure to regulate oxidative stress and inflammation results in lung damage. In the quest for innovative treatment strategies, phytochemicals, and complex plant extracts such as agarwood essential oil are promising sources of molecules with antioxidant and anti-inflammatory activity. However, their clinical use is limited by issues such as low solubility and poor pharmacokinetic properties. These can be overcome by encapsulating the therapeutic molecules using advanced drug delivery systems such as polymeric nanosystems and nanoemulsions. In this study, agarwood oil nanoemulsion (agarwood-NE) was formulated and tested for its antioxidant and anti-inflammatory potential in cigarette smoke extract (CSE)-treated BCi-NS1.1 airway basal epithelial cells. The findings suggest successful counteractivity of agarwood-NE against CSE-mediated pro-inflammatory effects by reducing the expression of the pro-inflammatory cytokines IL-1α, IL-1β, IL-8, and GDF-15. In addition, agarwood-NE induced the expression of the anti-inflammatory mediators IL-10, IL-18BP, TFF3, GH, VDBP, relaxin-2, IFN-γ, and PDGF. Furthermore, agarwood-NE also induced the expression of antioxidant genes such as GCLC and GSTP1, simultaneously activating the PI3K pro-survival signalling pathway. This study provides proof of the dual anti-inflammatory and antioxidant activity of agarwood-NE, highlighting its enormous potential for COPD treatment. Full article
(This article belongs to the Special Issue Mediterranean Nutrients and Oils)
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Review

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29 pages, 1448 KiB  
Review
Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production
by Fatiha Brahmi, Anne Vejux, Imen Ghzaiel, Mohamed Ksila, Amira Zarrouk, Taoufik Ghrairi, Soukena Essadek, Stéphane Mandard, Valerio Leoni, Giuseppe Poli, Dominique Vervandier-Fasseur, Omar Kharoubi, Adil El Midaoui, Atanas G. Atanasov, Smail Meziane, Norbert Latruffe, Boubker Nasser, Balkiss Bouhaouala-Zahar, Olfa Masmoudi-Kouki, Khodir Madani, Lila Boulekbache-Makhlouf and Gérard Lizardadd Show full author list remove Hide full author list
Nutrients 2022, 14(11), 2194; https://doi.org/10.3390/nu14112194 - 25 May 2022
Cited by 15 | Viewed by 7986
Abstract
Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This infectious disease has emerged in 2019. The COVID-19-associated pandemic has considerably affected the way of life and the economy in the world. It is consequently crucial [...] Read more.
Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This infectious disease has emerged in 2019. The COVID-19-associated pandemic has considerably affected the way of life and the economy in the world. It is consequently crucial to find solutions allowing remedying or alleviating the effects of this infectious disease. Natural products have been in perpetual application from immemorial time given that they are attested to be efficient towards several illnesses without major side effects. Various studies have shown that plant extracts or purified molecules have a promising inhibiting impact towards coronavirus. In addition, it is substantial to understand the characteristics, susceptibility and impact of diet on patients infected with COVID-19. In this review, we recapitulate the influence of extracts or pure molecules from medicinal plants on COVID-19. We approach the possibilities of plant treatment/co-treatment and feeding applied to COVID-19. We also show coronavirus susceptibility and complications associated with nutrient deficiencies and then discuss the major food groups efficient on COVID-19 pathogenesis. Then, we covered emerging technologies using plant-based SARS-CoV-2 vaccine. We conclude by giving nutrient and plants curative therapy recommendations which are of potential interest in the COVID-19 infection and could pave the way for pharmacological treatments or co-treatments of COVID-19. Full article
(This article belongs to the Special Issue Mediterranean Nutrients and Oils)
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20 pages, 1837 KiB  
Review
Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases
by Adil El Midaoui, Imen Ghzaiel, Dominique Vervandier-Fasseur, Mohamed Ksila, Amira Zarrouk, Thomas Nury, Farid Khallouki, Aboubaker El Hessni, Salama Ouazzani Ibrahimi, Norbert Latruffe, Réjean Couture, Omar Kharoubi, Fatiha Brahmi, Sonia Hammami, Olfa Masmoudi-Kouki, Mohamed Hammami, Taoufik Ghrairi, Anne Vejux and Gérard Lizard
Nutrients 2022, 14(3), 597; https://doi.org/10.3390/nu14030597 - 29 Jan 2022
Cited by 69 | Viewed by 19233
Abstract
Saffron (Crocus sativus L.) is a medicinal plant, originally cultivated in the East and Middle East, and later in some Mediterranean countries. Saffron is obtained from the stigmas of the plant. Currently, the use of saffron is undergoing a revival. The medicinal [...] Read more.
Saffron (Crocus sativus L.) is a medicinal plant, originally cultivated in the East and Middle East, and later in some Mediterranean countries. Saffron is obtained from the stigmas of the plant. Currently, the use of saffron is undergoing a revival. The medicinal virtues of saffron, its culinary use and its high added value have led to the clarification of its phytochemical profile and its biological and therapeutic characteristics. Saffron is rich in carotenoids and terpenes. The major products of saffron are crocins and crocetin (carotenoids) deriving from zeaxanthin, pirocrocin and safranal, which give it its taste and aroma, respectively. Saffron and its major compounds have powerful antioxidant and anti-inflammatory properties in vitro and in vivo. Anti-tumor properties have also been described. The goal of this review is to present the beneficial effects of saffron and its main constituent molecules on neuropsychiatric diseases (depression, anxiety and schizophrenia) as well as on the most frequent age-related diseases (cardiovascular, ocular and neurodegenerative diseases, as well as sarcopenia). Overall, the phytochemical profile of saffron confers many beneficial virtues on human health and, in particular, on the prevention of age-related diseases, which is a major asset reinforcing the interest for this medicinal plant. Full article
(This article belongs to the Special Issue Mediterranean Nutrients and Oils)
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