Molecular Stress Response Dysregulation in Cancer: Therapeutic Targets and Opportunities
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (1 April 2019) | Viewed by 75618
Special Issue Editor
Interests: oxidative stress; melanoma; skin cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The paradoxical combination of an age-related increase in cancer incidence and a demographic shift towards senescent populations has greatly exacerbated the role of cancer as a major medical challenge of global proportions, creating an urgent need for the discovery of novel molecular cancer therapeutics. Seminal research has provided cumulative evidence that oncogene-driven tumorigenesis dictates the dysregulated occurrence of genotoxic, mitotic, metabolic, proteotoxic, immunomodulatory, and redox stress responses. On the other hand, tumorigenic progression depends on the counter-regulatory activation of cytoprotective stress response pathways that represent a specific mechanistic vulnerability amenable to therapeutic intervention by molecularly targeted therapeutics. This special issue in ‘Cancers’ entitled ‘Molecular Stress Response Dysregulation in Cancer: Therapeutic Targets and Opportunities’ gathers original research and review papers positioned at the forefront of our current understanding of molecular stress response dysregulation in cancer, representing both a major pathological driving force and promising therapeutic target.
Dr. Georg T. WondrakGuest Editor
Manuscript Submission Information
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Keywords
- tumorigenesis
- cancer
- oncogene
- tumor suppressor
- redox dysregulation
- oxidative stress
- hypoxia
- proteotoxic stress
- autophagy
- ER stress
- genotoxic stress
- metabolic reprogramming
- oncometabolites
- tumor microenvironment
- immune evasion
- senescence
- apoptosis
- drug discovery
- molecularly targeted therapeutics
- immunotherapeutics