Mechanobiology in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 31596
Special Issue Editors
Interests: mechanotransduction; pancreatic cancer; liver cancer; microfluidics; tumor microenvironment
Interests: mechanobiology; mechanotransduction; cancer biomechanics; pancreatic cancer; in vitro models; cell mechanics; biomaterials; stem cell biology
Special Issue Information
Dear Colleagues,
The past decade has provided increasing evidence that the biophysical features of the tumor microenvironment act to modulate both cancer and stromal cell function. Understanding the role of genetic mutations and their associated biochemical signaling pathways in the onset and progression of cancer has been the focus of cancer research since the advent of sequencing technology. However, there is a reciprocal interplay between biochemical and biophysical signaling which influences cancer hallmarks including migration, metastasis, and angiogenesis. All cells are subjected to forces transmitted through the bulk tissue, or locally through cell–cell and cell–extracellular matrix (ECM) interactions. Through mechanotransduction, these forces can activate tumorigenic biochemical pathways in cancer and stromal cells, leading to cancer progression, metastasis, and therapy resistance.
This Special Issue will highlight the many roles of mechanobiology in cancer, from primary tumor initiation to metastatic progression and drug resistance. We welcome article, review or perspective submissions spanning all aspects of cancer mechanobiology from basic mechanotransduction at the cellular and subcellular scales to translational studies incorporating mechanotherapeutics to target the physical properties of the tumor.
Dr. Armando del Río Hernández
Dr. Stephen D. Thorpe
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mechanobiology
- cancer
- mechanotransduction
- tumor microenvironment
- tissue mechanics
- cell mechanics
- metastasis
- cell adhesion
- extracellular matrix
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