Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 22272
Special Issue Editor
Interests: DNA methylation; cancer invasion and metastasis in breast and pancreatic cancers; carcinoma-associated fibroblasts; epithelial–mesenchymal transition; AKT signaling pathway; tumor microenvironment and immune evasion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It was widely recognized that the complex interplay between immunity and cancer determines whether cancer cells will survive or be destroyed. The battle between tumoricidal and tumor promoting activity relies on the extent to which the antitumor immune response is exerted. In general, immune evasive mechanisms adapted by cancers encompass downregulation of antigen presentations or recognition, lack of immune effector cells, obstruction of antitumor immune cell maturation, accumulation of immunosuppressive cells, production of inhibitory cytokines, chemokines or ligands/receptors, establishment of a hypoxic tumor microenvironment, development of cancer-promoting metabolisms, and upregulation of immune checkpoint modulators. As such, restoring or stimulating tumoricidal effects, in conjunction with surgical resection, as well as chemo- or radiation-mediated, hormone-based, kinase-targeted, DNA repair-disrupted, small molecule inhibitor-mediated, signal transduction pathway-modified, aberrant epigenome-reverted, and cytokine-involved treatments, may ignite promising therapeutic regiments to eradicate fatal cancers. This Special Issue welcomes papers outlining mechanisms of immune escape or depicting strategies for boosting immune surveillance, in synergy with additional non-immune interventions to eradicate human cancers.
Dr. Huey-Jen Lin
Guest Editor
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Keywords
- CD8+ tumor-infiltrating lymphocytes
- cytotoxic T lymphocytes -associated protein 4
- dendritic cells
- immune evasion
- hypoxia-inducible factors
- myeloid-derived suppressor cells
- natural killer
- programmed death receptor and ligand
- regulatory T cells
- tumor-associated macrophages
- tumor microenvironment
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