Special Issue "NF-kappaB signalling pathway"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 22460
This Special Issue is about the NF-kappaB signalling pathway and its pleiotropic effects on different aspects of cancer, including oncogenesis and therapy resistance. Originally described in the context of inflammation, a huge amount of excellent work has been done to describe the role of NF-kappab as a central tumor-promoting signalling pathway in inflammation-associated cancer. Furthermore, components of the pathway and the NF-kappab subunits itself are frequently genetically altered in tumors. In addition, emerging data demonstrate that NF-kappab signalling is involved in different aspects of therapy resistance. In addition to the tumor cell-intrinsic function, this signalling pathway has been shown to be crucial in mediating onco-immuno signalling and in the regulation of the tumor microenvironment of several tumor entities. Furthermore, NF-kappaB is involved in aspects like metabolism, immunity, epigenetic regulation, and all kinds of cell deaths, predestining this signalling pathway to be one of the most attractive molecular targets in cancer therapy. However, some very eloquent publications have raised the issue that under certain conditions NF-kappaB can act as a direct tumor suppressor and also mediate anti-tumor immune responses, presenting a dilemma when designing NF-kappaB targeting anti-tumor therapies.
Here, we welcome papers outlining the recent anti- but also the pro-tumorigenic role of NF-kappaB.
Prof. Dr. Alexander Arlt
Manuscript Submission Information
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