Matrix Effectors and Cancer

Dear Colleagues,

Extracellular matrices (ECMs) are highly dynamic three-dimensional structural meshworks composed of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, elastin, glycoproteins and proteinases. Matrix macromolecules are characterized by high structural complexity and heterogeneity. They form complex networks through which they dynamically communicate with cells, thus serving as critical regulators of several homeostatic and pathological processes, such as cancer. ECM molecular composition varies among the tissue of origin and it undergoes significant remodeling during cancer progression. The elucidation of the mechanistic aspects governing matrix assembly and cell–matrix interactions is of critical importance to discover matrix-mediated cancer pathobiology and novel therapeutic approaches. The aim of this Collection of Cancers is to highlight the emerging roles of effective matrix macromolecules, including matrix metalloproteinases, proteoglycans, specific types of collagens and matrix (glyco)proteins that play key roles in cancer development and aggressiveness.

Prof. Dr. Nikos Karamanos
Dr. Zoi Piperigkou
Collection Editors

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