Novel Perspectives of ctDNA-Based Liquid Biopsy in Oncology

Dear Colleagues,

Fragmented DNA in body fluids originating from tumor cells, also known as circulating tumor DNA (ctDNA), has drawn considerable scientific and clinical attention as a biomarker for various cancers. ctDNA testing examines a patient’s body fluid (mainly blood) to detect DNA fragments from cancer cells. Recent advances in next-generation sequencing (NGS) and polymerase chain reaction (PCR) technologies have led ctDNA to become the predominant biomarker of liquid biopsies to understand the tumor status of a patient and explore the genetic landscape of cancer. Specifically, accumulating evidence has revealed that the detection of cancer-specific gene mutation or amplification in body fluid is strongly associated with a poor prognosis.

In this Special Issue on “Novel Perspectives of ctDNA-Based Liquid biopsy in Oncology”, we aim to cover all aspects of the sciences, processes, and engineering techniques related to the development and analysis of liquid biopsy systems using ctDNA as a tumor biomarker. This issue will also highlight clinical trials of ctDNA in diagnosing and characterizing tumor, as well as monitoring and estimating prognoses.

Dr. Jiyoon Bu
Guest Editor

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