Inflammation, Immunity, and Cancer Progression: 2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 1 August 2025 | Viewed by 2235

Special Issue Editors


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Guest Editor
Division of Hematology & Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Interests: animal health; diagnosis; immunology; parasitology; animal nutrition
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Guest Editor
Department of Immunology and Microbiology, South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA
Interests: basic mechanisms of cancer progression; health disparities; pre-clinical drug development; miRNA; lncRNAs; snoRNAs; nano-technology therapies; antibody-drug conjugates; exosome-mediated drug delivery
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Guest Editor
Seattle Children’s Research Institute, Seattle, CA, USA
Interests: cancer immunology; inflammation and autoimmunity; molecular immunology; developmental immunology; gene editing and cell therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic inflammation plays a significant role in cancer initiation, progression, metastasis, and chemoresistance. Additionally, cancer-related inflammation is the seventh hallmark of cancer and is associated with genetic instability. Genomic and epigenomic mechanisms are essential in the establishment of cellular programs in cancer and immune cells. The dysregulation of these mechanisms contributes to tumor growth. Transcriptional and epigenetic changes during inflammatory conditions have revealed histone modifications and transcriptional signatures that define the dysregulation of cellular function in cancer and immune cells. Eventually, discovering a core set of regulators that can regulate functions in these cells, such as transcription factors, epigenetic regulatory molecules, and signaling molecules, may be sufficient to help reprogram terminally differentiated immune cells. Such findings are certainly having an impact on immune cell-based therapies.

Recent advances in cancer and immune cell genomics and immune cell engineering have therapeutic implications and provide discourse on the challenges and perspectives associated with the emerging role of transcriptional, epigenetic, and metabolic regulation in cancer and immunity.

This Special Issue will highlight the latest experimental advances and technical developments in genomics and epigenomics, gene editing, gene delivery, and therapeutic approaches for studying immune regulation in immune-mediated diseases, including autoimmunity and cancer. The aim of this Special Issue is to address this broad field through a series of high-quality, multidisciplinary research articles that discuss a range of subjects regarding the transcriptional and epigenetic regulation of inflammation during cancer and immunity. We will consider original research, methodology, review articles, and short reports.

This Special Issue welcomes the submission of outstanding contributions to the fields of cancer and immunity that include, but are not limited to, the following topics:

  • Inflammation in cancer immunity;
  • Transcriptional and epigenetic regulations in cancer cells and immune cell differentiation and development;
  • Transcriptomics and epigenomics of immune-mediated diseases;
  • Immunometabolism;
  • Pharmacogenomic of diseases;
  • Integration of Bioinformatics Data.

Dr. Deepak Parashar
Dr. Vivek K. Kashyap
Dr. Subhash Tripathi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • cancer immunity
  • transcriptomics
  • epigenomics
  • immunometabolism
  • pharmacogenomic
  • bioinformatics data
  • immunopharmacogenomics

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Published Papers (1 paper)

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Review

32 pages, 2615 KiB  
Review
KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy
by Priyanka Uniyal, Vivek Kumar Kashyap, Tapan Behl, Deepak Parashar and Ravi Rawat
Cancers 2025, 17(5), 785; https://doi.org/10.3390/cancers17050785 - 25 Feb 2025
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Abstract
The Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation is one of the most prevailing mutations in various tumors and is difficult to cure. Long-term proliferation in carcinogenesis is primarily initiated by oncogenic KRAS-downstream signaling. Recent research suggests that it also activates the [...] Read more.
The Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation is one of the most prevailing mutations in various tumors and is difficult to cure. Long-term proliferation in carcinogenesis is primarily initiated by oncogenic KRAS-downstream signaling. Recent research suggests that it also activates the autocrine effect and interplays the tumor microenvironment (TME). Here, we discuss the emerging research, including KRAS mutations to immune evasion in TME, which induce immunological modulation that promotes tumor development. This review gives an overview of the existing knowledge of the underlying connection between KRAS mutations and tumor immune modulation. It also addresses the mechanisms to reduce the effect of oncogenes on the immune system and recent advances in clinical trials for immunotherapy in KRAS-mutated cancers. Full article
(This article belongs to the Special Issue Inflammation, Immunity, and Cancer Progression: 2nd Edition)
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