Advances in Salivary Gland Carcinoma: 2nd Edition

Dear Colleagues,

This Special Issue is the second edition of a previous issue on the topic of "Advances in Salivary Gland Carcinoma” (https://www.mdpi.com/journal/cancers/special_issues/T9Y6IQU800). Salivary gland malignancies represent one of the most complex groups of tumors from a pathological point of view. They show a striking range of morphological diversity between different tumor types. In fact, all the WHO classifications that have occurred over time report more than 20 histotypes. Furthermore, the rarity of some of these histotypes requires a skilled pathologist for diagnosis. Parotid tumors are far more common than neoplasms in the other sites (70–80%), but only 20% are malignant. Approximately 50% of the tumors in the submandibular gland and 70% of those in the minor salivary glands are malignant. Because of the high frequency of parotid tumors, despite the low rate of malignant ones, parotid malignancies are more common than those of other salivary glands.

It is almost universally established that the diagnostic work-up should include FNA, in addition to CT and/or MRI, when needed.

Upfront surgery is the most appropriate treatment for resectable tumors. The attitude towards parotid tumors that come into contact with the facial nerve is controversial (preservation with post-operative radiotherapy or resection and reconstruction). Another controversial question is the prophylactic neck dissection in N0 patients.

These and other topics related to salivary gland carcinomas will be covered in this Special Issue.

Dr. Giulio Cantù
Guest Editor

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